Abstract
A rapid method for the reduction of secondary phosphine oxides under mild conditions has been developed, allowing simple isolation of the corresponding free phosphines. The methodology involves the use of pinacol borane (HBpin) to effect the reduction while circumventing the formation of a phosphine borane adduct, as is usually the case with various other commonly used borane reducing agents such as borane tetrahydrofuran complex (BH 3⋅THF) and borane dimethyl sulfide complex (BH 3⋅SMe 2). In addition, this methodology requires only a small excess of reducing agent and therefore compares favourably not just with other borane reductants that do not require a metal co-catalyst, but also with silane and aluminium based reagents. (Figure presented.).
Original language | English |
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Pages (from-to) | 3999-4004 |
Number of pages | 6 |
Journal | Advanced Synthesis & Catalysis |
Volume | 360 |
Issue number | 20 |
Early online date | 13 Aug 2018 |
DOIs | |
Publication status | Published - 31 Oct 2018 |
Keywords
- Phosphine oxide
- pinacol borane
- reduction
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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Emma Emanuelsson Patterson
- Department of Chemical Engineering - Senior Lecturer
- Reaction and Catalysis Engineering research unit (RaCE)
- Water Innovation and Research Centre (WIRC)
- EPSRC Centre for Doctoral Training in Statistical Applied Mathematics (SAMBa)
- Institute for Mathematical Innovation (IMI)
- Centre for Integrated Bioprocessing Research (CIBR)
Person: Research & Teaching