Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas

Kaisa Thorell, Koji Yahara, Elvire Berthenet, Daniel J. Lawson, Jane Mikhail, Ikuko Kato, Alfonso Mendez, Cosmeri Rizzato, María Mercedes Bravo, Rumiko Suzuki, Yoshio Yamaoka, Javier Torres, Samuel K. Sheppard, Daniel Falush

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

For the last 500 years, the Americas have been a melting pot both for genetically diverse humans and for the pathogenic and commensal organisms associated with them. One such organism is the stomach-dwelling bacterium Helicobacter pylori, which is highly prevalent in Latin America where it is a major current public health challenge because of its strong association with gastric cancer. By analyzing the genome sequence of H. pylori isolated in North, Central and South America, we found evidence for admixture between H. pylori of European and African origin throughout the Americas, without substantial input from pre-Columbian (hspAmerind) bacteria. In the US, strains of African and European origin have remained genetically distinct, while in Colombia and Nicaragua, bottlenecks and rampant genetic exchange amongst isolates have led to the formation of national gene pools. We found three outer membrane proteins with atypical levels of Asian ancestry in American strains, as well as alleles that were nearly fixed specifically in South American isolates, suggesting a role for the ethnic makeup of hosts in the colonization of incoming strains. Our results show that new H. pylori subpopulations can rapidly arise, spread and adapt during times of demographic flux, and suggest that differences in transmission ecology between high and low prevalence areas may substantially affect the composition of bacterial populations.

Original languageEnglish
Article numbere1006546
Pages (from-to)1-21
Number of pages21
JournalPlos Genetics
Volume13
Issue number2
DOIs
Publication statusPublished - 23 Feb 2017

Fingerprint

Helicobacter pylori
subpopulation
bacterium
commensal
ancestry
public health
cancer
allele
colonization
genome
Nicaragua
membrane
ecology
Bacteria
Gene Pool
Central America
protein
Colombia
stomach neoplasms
Latin America

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

Cite this

Thorell, K., Yahara, K., Berthenet, E., Lawson, D. J., Mikhail, J., Kato, I., ... Falush, D. (2017). Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas. Plos Genetics, 13(2), 1-21. [e1006546]. https://doi.org/10.1371/journal.pgen.1006546

Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas. / Thorell, Kaisa; Yahara, Koji; Berthenet, Elvire; Lawson, Daniel J.; Mikhail, Jane; Kato, Ikuko; Mendez, Alfonso; Rizzato, Cosmeri; Bravo, María Mercedes; Suzuki, Rumiko; Yamaoka, Yoshio; Torres, Javier; Sheppard, Samuel K.; Falush, Daniel.

In: Plos Genetics, Vol. 13, No. 2, e1006546, 23.02.2017, p. 1-21.

Research output: Contribution to journalArticle

Thorell, K, Yahara, K, Berthenet, E, Lawson, DJ, Mikhail, J, Kato, I, Mendez, A, Rizzato, C, Bravo, MM, Suzuki, R, Yamaoka, Y, Torres, J, Sheppard, SK & Falush, D 2017, 'Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas', Plos Genetics, vol. 13, no. 2, e1006546, pp. 1-21. https://doi.org/10.1371/journal.pgen.1006546
Thorell K, Yahara K, Berthenet E, Lawson DJ, Mikhail J, Kato I et al. Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas. Plos Genetics. 2017 Feb 23;13(2):1-21. e1006546. https://doi.org/10.1371/journal.pgen.1006546
Thorell, Kaisa ; Yahara, Koji ; Berthenet, Elvire ; Lawson, Daniel J. ; Mikhail, Jane ; Kato, Ikuko ; Mendez, Alfonso ; Rizzato, Cosmeri ; Bravo, María Mercedes ; Suzuki, Rumiko ; Yamaoka, Yoshio ; Torres, Javier ; Sheppard, Samuel K. ; Falush, Daniel. / Rapid evolution of distinct Helicobacter pylori subpopulations in the Americas. In: Plos Genetics. 2017 ; Vol. 13, No. 2. pp. 1-21.
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