Rapid determination of enantiomeric excess via NMR spectroscopy

A research-informed experiment

John S. Fossey, Eric V. Anslyn, William D.G. Brittain, Steven D. Bull, Brette M. Chapin, Cécile S. Le Duff, Tony D. James, Glenn Lees, Stephanie Lim, Jennifer A.C. Lloyd, Charles V. Manville, Daniel T. Payne, Kimberley A. Roper

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by 1H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalJournal of Chemical Education
Volume94
Issue number1
DOIs
Publication statusPublished - 10 Jan 2017

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Nuclear magnetic resonance spectroscopy
experiment
Experiments
Teaching
chemistry
Students
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Keywords

  • Analytical chemistry
  • Chirality/optical activity
  • Computer-based learning
  • Enantiomers
  • Hands-on learning/manipulatives
  • Laboratory instruction
  • NMR spectroscopy
  • Organic chemistry
  • Second-year undergraduate
  • Stereochemistry

ASJC Scopus subject areas

  • Chemistry(all)
  • Education

Cite this

Fossey, J. S., Anslyn, E. V., Brittain, W. D. G., Bull, S. D., Chapin, B. M., Le Duff, C. S., ... Roper, K. A. (2017). Rapid determination of enantiomeric excess via NMR spectroscopy: A research-informed experiment. Journal of Chemical Education, 94(1), 79-84. https://doi.org/10.1021/acs.jchemed.6b00355

Rapid determination of enantiomeric excess via NMR spectroscopy : A research-informed experiment. / Fossey, John S.; Anslyn, Eric V.; Brittain, William D.G.; Bull, Steven D.; Chapin, Brette M.; Le Duff, Cécile S.; James, Tony D.; Lees, Glenn; Lim, Stephanie; Lloyd, Jennifer A.C.; Manville, Charles V.; Payne, Daniel T.; Roper, Kimberley A.

In: Journal of Chemical Education, Vol. 94, No. 1, 10.01.2017, p. 79-84.

Research output: Contribution to journalArticle

Fossey, JS, Anslyn, EV, Brittain, WDG, Bull, SD, Chapin, BM, Le Duff, CS, James, TD, Lees, G, Lim, S, Lloyd, JAC, Manville, CV, Payne, DT & Roper, KA 2017, 'Rapid determination of enantiomeric excess via NMR spectroscopy: A research-informed experiment', Journal of Chemical Education, vol. 94, no. 1, pp. 79-84. https://doi.org/10.1021/acs.jchemed.6b00355
Fossey, John S. ; Anslyn, Eric V. ; Brittain, William D.G. ; Bull, Steven D. ; Chapin, Brette M. ; Le Duff, Cécile S. ; James, Tony D. ; Lees, Glenn ; Lim, Stephanie ; Lloyd, Jennifer A.C. ; Manville, Charles V. ; Payne, Daniel T. ; Roper, Kimberley A. / Rapid determination of enantiomeric excess via NMR spectroscopy : A research-informed experiment. In: Journal of Chemical Education. 2017 ; Vol. 94, No. 1. pp. 79-84.
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