TY - JOUR
T1 - Rapid determination of enantiomeric excess via NMR spectroscopy
T2 - A research-informed experiment
AU - Fossey, John S.
AU - Anslyn, Eric V.
AU - Brittain, William D.G.
AU - Bull, Steven D.
AU - Chapin, Brette M.
AU - Le Duff, Cécile S.
AU - James, Tony D.
AU - Lees, Glenn
AU - Lim, Stephanie
AU - Lloyd, Jennifer A.C.
AU - Manville, Charles V.
AU - Payne, Daniel T.
AU - Roper, Kimberley A.
PY - 2017/1/10
Y1 - 2017/1/10
N2 - An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by 1H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment.
AB - An undergraduate chemistry experiment that draws from primary research is described. The experiment exploits chiral supramolecular assemblies for the determination of enantiomeric excess by 1H NMR spectroscopy. This report describes the delivery of the experiment to a cohort of students, and as a result of feedback from those involved, an optimized protocol is presented. Particular care has been taken to facilitate ready adoption in other institutions by providing comprehensive teaching support materials as well as technical guidance for supporting the experiment.
KW - Analytical chemistry
KW - Chirality/optical activity
KW - Computer-based learning
KW - Enantiomers
KW - Hands-on learning/manipulatives
KW - Laboratory instruction
KW - NMR spectroscopy
KW - Organic chemistry
KW - Second-year undergraduate
KW - Stereochemistry
UR - http://www.scopus.com/inward/record.url?scp=85016267891&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1021/acs.jchemed.6b00355
U2 - 10.1021/acs.jchemed.6b00355
DO - 10.1021/acs.jchemed.6b00355
M3 - Article
AN - SCOPUS:85016267891
SN - 0021-9584
VL - 94
SP - 79
EP - 84
JO - Journal of Chemical Education
JF - Journal of Chemical Education
IS - 1
ER -