RADIOLABELED MOEM TYPE OLIGONUCLEOTIDES AND PROCESS FOR THEIR PREPARATION

Martin Edelmann; Thorsten Muser

RADIOLABELED MOEM TYPE OLIGONUCLEOTIDES AND PROCESS FOR THEIR PREPARATION

Martin Edelmann (Inventor)
, Thorsten Muser (Inventor)

Department of Life Sciences

Hoffmann La Roche Ltd

Research output: Patent

Abstract

The invention comprises radiolabeled MOEM type oligonucleotide of the formula (I), (I) wherein n, X1, X2, the linker (1), the linker (2), Q* and the receptor targeting moiety are as defined (I) the description. The radiolabeled oligonucleotides of the formula (I) can be used for the determination of the biodistribution and pharmacokinetics of the oligonucleotide in the tissue or body fluid.

Original language	English
Patent number	WO/2020/254548
IPC	C07H 1/00 2006.01,C07H 21/00 2006.01,G01N 33/60 2006.01,A61K 51/04 2006.01
Priority date	20/06/20
Filing date	19/06/20
Publication status	Published - 24 Dec 2021

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title = "RADIOLABELED MOEM TYPE OLIGONUCLEOTIDES AND PROCESS FOR THEIR PREPARATION",

abstract = "The invention comprises radiolabeled MOEM type oligonucleotide of the formula (I), (I) wherein n, X1, X2, the linker (1), the linker (2), Q* and the receptor targeting moiety are as defined (I) the description. The radiolabeled oligonucleotides of the formula (I) can be used for the determination of the biodistribution and pharmacokinetics of the oligonucleotide in the tissue or body fluid.",

author = "Martin Edelmann and Thorsten Muser",

year = "2021",

month = dec,

day = "24",

language = "English",

type = "Patent",

note = "WO/2020/254548; C07H 1/00 2006.01,C07H 21/00 2006.01,G01N 33/60 2006.01,A61K 51/04 2006.01",

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TY - PAT

T1 - RADIOLABELED MOEM TYPE OLIGONUCLEOTIDES AND PROCESS FOR THEIR PREPARATION

AU - Edelmann, Martin

AU - Muser, Thorsten

PY - 2021/12/24

Y1 - 2021/12/24

N2 - The invention comprises radiolabeled MOEM type oligonucleotide of the formula (I), (I) wherein n, X1, X2, the linker (1), the linker (2), Q* and the receptor targeting moiety are as defined (I) the description. The radiolabeled oligonucleotides of the formula (I) can be used for the determination of the biodistribution and pharmacokinetics of the oligonucleotide in the tissue or body fluid.

AB - The invention comprises radiolabeled MOEM type oligonucleotide of the formula (I), (I) wherein n, X1, X2, the linker (1), the linker (2), Q* and the receptor targeting moiety are as defined (I) the description. The radiolabeled oligonucleotides of the formula (I) can be used for the determination of the biodistribution and pharmacokinetics of the oligonucleotide in the tissue or body fluid.

M3 - Patent

M1 - WO/2020/254548

Y2 - 2020/06/19

ER -

RADIOLABELED MOEM TYPE OLIGONUCLEOTIDES AND PROCESS FOR THEIR PREPARATION

Abstract

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