Radio- and nano-chemistry of aqueous Ga(III) ions anchored onto graphene oxide-modified complexes

S. Sarpaki; F. Cortezon-Tamarit; S. R.M.M. De Aguiar; R. M. Exner; D. Divall; R. L. Arrowsmith; H. Ge; F. J. Palomares; L. Carroll; D. G. Calatayud; S. J. Paisey; E. O. Aboagye; S. I. Pascu

doi:10.1039/c9nr10145d

Radio- and nano-chemistry of aqueous Ga(III) ions anchored onto graphene oxide-modified complexes

S. Sarpaki, F. Cortezon-Tamarit, S. R.M.M. De Aguiar, R. M. Exner, D. Divall, R. L. Arrowsmith, H. Ge, F. J. Palomares, L. Carroll, D. G. Calatayud, S. J. Paisey, E. O. Aboagye, S. I. Pascu

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

12 Citations (SciVal)

Abstract

The gallium-68 radiolabelling of new functional graphene oxide composites is reported herein along with kinetic stability investigations of the radio-nanohybrids under different environments and insights into their surface characteristics by SEM and XPS. The present work highlights the potential of graphene oxides as nanocarriers for small molecules such as bis(thiosemicarbazonato) complexes to act as multifunctional platforms for rapid and effective radioimaging agent incorporation.

Original language	English
Pages (from-to)	6603-6608
Number of pages	6
Journal	Nanoscale
Volume	12
Issue number	12
Early online date	17 Mar 2020
DOIs	https://doi.org/10.1039/c9nr10145d
Publication status	Published - 28 Mar 2020

Funding

The S. I. P. group thanks the Centre for Doctoral Training in Sustainable Chemical Technologies (EP/L016354/1). SIP also acknowledges the EU funding through the ERC for the Consolidator Grant O2SENSE (617107, 2014–2020). The authors thank EPSRC National Service for Mass Spectrometry at Swansea and for data collection. We thank Professor Stan Botchway for training in confocal fluorescence microscopy and Professor Jon Dilworth for helpful discussions in the radiochemistry of bis(thiosemicarbazones). The EOA group acknowledges support from Imperial College NIHR Biomedical Research Centre, Cancer Research UK (C2536/A16584) and the UK Medical Research Council (MR/J007986/1). D. G. C. also acknowledges the Fundación General CSIC (ComFuturo Program) for the financial support and F. J. P. the Spanish Ministry of Economy and Competitiveness (MINECO) (MAT2016-80394-R).

ASJC Scopus subject areas

General Materials Science

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Sarpaki, S., Cortezon-Tamarit, F., De Aguiar, S. R. M. M., Exner, R. M., Divall, D., Arrowsmith, R. L., Ge, H., Palomares, F. J., Carroll, L., Calatayud, D. G., Paisey, S. J., Aboagye, E. O., & Pascu, S. I. (2020). Radio- and nano-chemistry of aqueous Ga(III) ions anchored onto graphene oxide-modified complexes. Nanoscale, 12(12), 6603-6608. https://doi.org/10.1039/c9nr10145d

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abstract = "The gallium-68 radiolabelling of new functional graphene oxide composites is reported herein along with kinetic stability investigations of the radio-nanohybrids under different environments and insights into their surface characteristics by SEM and XPS. The present work highlights the potential of graphene oxides as nanocarriers for small molecules such as bis(thiosemicarbazonato) complexes to act as multifunctional platforms for rapid and effective radioimaging agent incorporation.",

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AU - Cortezon-Tamarit, F.

AU - De Aguiar, S. R.M.M.

AU - Exner, R. M.

AU - Divall, D.

AU - Arrowsmith, R. L.

AU - Ge, H.

AU - Palomares, F. J.

AU - Carroll, L.

AU - Calatayud, D. G.

AU - Paisey, S. J.

AU - Aboagye, E. O.

AU - Pascu, S. I.

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AB - The gallium-68 radiolabelling of new functional graphene oxide composites is reported herein along with kinetic stability investigations of the radio-nanohybrids under different environments and insights into their surface characteristics by SEM and XPS. The present work highlights the potential of graphene oxides as nanocarriers for small molecules such as bis(thiosemicarbazonato) complexes to act as multifunctional platforms for rapid and effective radioimaging agent incorporation.

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Radio- and nano-chemistry of aqueous Ga(III) ions anchored onto graphene oxide-modified complexes

Abstract

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ASJC Scopus subject areas

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