TY - JOUR
T1 - Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines
AU - Elmasry, M S
AU - Blagbrough, Ian S
AU - Rowan, Michael G
AU - Saleh, H M
AU - Kheir, A A
AU - Rogers, Philip J
PY - 2011/3/25
Y1 - 2011/3/25
N2 - An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines when stored, with other medications, in Venalink blister packs (monitored dosage system) for periods of up to 35 days. Chromatographic separation was achieved on a reversed-phase C-12 column with an isocratic mixture of methanol, water and acetic acid as the mobile phase. The method was validated regarding: accuracy, precision, detection limits, quantification limits, specificity and robustness.
AB - An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines when stored, with other medications, in Venalink blister packs (monitored dosage system) for periods of up to 35 days. Chromatographic separation was achieved on a reversed-phase C-12 column with an isocratic mixture of methanol, water and acetic acid as the mobile phase. The method was validated regarding: accuracy, precision, detection limits, quantification limits, specificity and robustness.
KW - mebeverine
KW - aspirin
KW - mesalazine
KW - 5-Aminosalicylic acid
KW - sulphasalazine
UR - http://www.scopus.com/inward/record.url?scp=78650253701&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1016/j.jpba.2010.10.002
U2 - 10.1016/j.jpba.2010.10.002
DO - 10.1016/j.jpba.2010.10.002
M3 - Article
SN - 0731-7085
VL - 54
SP - 646
EP - 652
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
IS - 4
ER -