Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines

M S Elmasry, Ian S Blagbrough, Michael G Rowan, H M Saleh, A A Kheir, Philip J Rogers

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An HPLC method for the quantitative analysis of mebeverine HCl, 5-aminosalicylic acid (5-ASA), sulphasalazine and dispersible aspirin has been developed and then applied to these specific medicines when stored, with other medications, in Venalink blister packs (monitored dosage system) for periods of up to 35 days. Chromatographic separation was achieved on a reversed-phase C-12 column with an isocratic mixture of methanol, water and acetic acid as the mobile phase. The method was validated regarding: accuracy, precision, detection limits, quantification limits, specificity and robustness.
Original languageEnglish
Pages (from-to)646-652
Number of pages7
JournalJournal of Pharmaceutical and Biomedical Analysis
Issue number4
Publication statusPublished - 25 Mar 2011



  • mebeverine
  • aspirin
  • mesalazine
  • 5-Aminosalicylic acid
  • sulphasalazine

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