Quantification of biomarker functionality predicts patient outcomes

Banafshé Larijani; James Miles; Stephen G. Ward; Peter J. Parker

doi:10.1038/s41416-021-01291-3

Quantification of biomarker functionality predicts patient outcomes

Banafshé Larijani, James Miles, Stephen G. Ward, Peter J. Parker

Research output: Contribution to journal › Comment/debate › peer-review

6 Citations (SciVal)

Abstract

Implementation of a quantitative molecular imaging method (iFRET), which determines receptor–ligand interactions, has led to the finding that patients with a low extent of PD-1/PD-L1 interaction in metastatic NSCLC, and malignant melanoma, display significantly worsened overall survival compared to those with a high level of interaction.

Original language	English
Pages (from-to)	1618-1620
Number of pages	3
Journal	British Journal of Cancer
Volume	124
Issue number	10
Early online date	15 Mar 2021
DOIs	https://doi.org/10.1038/s41416-021-01291-3
Publication status	Published - 11 May 2021

Bibliographical note

Funding Information:
Funding information The original research was supported, in part, by Department of Education, Basque Government-IT1270-19, Elkartek grant (BG18) and the Spanish Ministry grant (MINECO) PROJECTS of EXCELLENCE (BFU2015-65625-P). P.J.P. was supported by a core grant to the Francis Crick Institute, from Cancer Research UK (FC001130), the UK Medical Research Council (FC001130) and the Wellcome Trust (FC001130).

Funding

Funding information The original research was supported, in part, by Department of Education, Basque Government-IT1270-19, Elkartek grant (BG18) and the Spanish Ministry grant (MINECO) PROJECTS of EXCELLENCE (BFU2015-65625-P). P.J.P. was supported by a core grant to the Francis Crick Institute, from Cancer Research UK (FC001130), the UK Medical Research Council (FC001130) and the Wellcome Trust (FC001130).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/s41416-021-01291-3Licence: CC BY

Cite this

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title = "Quantification of biomarker functionality predicts patient outcomes",

abstract = "Implementation of a quantitative molecular imaging method (iFRET), which determines receptor–ligand interactions, has led to the finding that patients with a low extent of PD-1/PD-L1 interaction in metastatic NSCLC, and malignant melanoma, display significantly worsened overall survival compared to those with a high level of interaction.",

author = "Banafsh{\'e} Larijani and James Miles and Ward, \{Stephen G.\} and Parker, \{Peter J.\}",

note = "Funding Information: Funding information The original research was supported, in part, by Department of Education, Basque Government-IT1270-19, Elkartek grant (BG18) and the Spanish Ministry grant (MINECO) PROJECTS of EXCELLENCE (BFU2015-65625-P). P.J.P. was supported by a core grant to the Francis Crick Institute, from Cancer Research UK (FC001130), the UK Medical Research Council (FC001130) and the Wellcome Trust (FC001130). ",

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doi = "10.1038/s41416-021-01291-3",

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T1 - Quantification of biomarker functionality predicts patient outcomes

AU - Larijani, Banafshé

AU - Miles, James

AU - Ward, Stephen G.

AU - Parker, Peter J.

N1 - Funding Information: Funding information The original research was supported, in part, by Department of Education, Basque Government-IT1270-19, Elkartek grant (BG18) and the Spanish Ministry grant (MINECO) PROJECTS of EXCELLENCE (BFU2015-65625-P). P.J.P. was supported by a core grant to the Francis Crick Institute, from Cancer Research UK (FC001130), the UK Medical Research Council (FC001130) and the Wellcome Trust (FC001130).

PY - 2021/5/11

Y1 - 2021/5/11

N2 - Implementation of a quantitative molecular imaging method (iFRET), which determines receptor–ligand interactions, has led to the finding that patients with a low extent of PD-1/PD-L1 interaction in metastatic NSCLC, and malignant melanoma, display significantly worsened overall survival compared to those with a high level of interaction.

AB - Implementation of a quantitative molecular imaging method (iFRET), which determines receptor–ligand interactions, has led to the finding that patients with a low extent of PD-1/PD-L1 interaction in metastatic NSCLC, and malignant melanoma, display significantly worsened overall survival compared to those with a high level of interaction.

UR - https://www.scopus.com/pages/publications/85102596187

U2 - 10.1038/s41416-021-01291-3

DO - 10.1038/s41416-021-01291-3

M3 - Comment/debate

AN - SCOPUS:85102596187

SN - 0007-0920

VL - 124

SP - 1618

EP - 1620

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 10

ER -

Quantification of biomarker functionality predicts patient outcomes

Abstract

Bibliographical note

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

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