Quantification of biomarker functionality predicts patient outcomes

Banafshé Larijani, James Miles, Stephen G. Ward, Peter J. Parker

Research output: Contribution to journalComment/debatepeer-review

3 Citations (SciVal)

Abstract

Implementation of a quantitative molecular imaging method (iFRET), which determines receptor–ligand interactions, has led to the finding that patients with a low extent of PD-1/PD-L1 interaction in metastatic NSCLC, and malignant melanoma, display significantly worsened overall survival compared to those with a high level of interaction.

Original languageEnglish
Pages (from-to)1618-1620
Number of pages3
JournalBritish Journal of Cancer
Volume124
Issue number10
Early online date15 Mar 2021
DOIs
Publication statusPublished - 11 May 2021

Bibliographical note

Funding Information:
Funding information The original research was supported, in part, by Department of Education, Basque Government-IT1270-19, Elkartek grant (BG18) and the Spanish Ministry grant (MINECO) PROJECTS of EXCELLENCE (BFU2015-65625-P). P.J.P. was supported by a core grant to the Francis Crick Institute, from Cancer Research UK (FC001130), the UK Medical Research Council (FC001130) and the Wellcome Trust (FC001130).

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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