Puberty and traumatic brain injury

J. Bryce Ortiz, Tabitha R.F. Green, Giri Rampal, Rachel K. Rowe

Research output: Chapter or section in a book/report/conference proceedingChapter or section

Abstract

Traumatic brain injuries (TBI) in children are a leading cause of death and disability worldwide. Individuals who survive pediatric TBI can be left with lifelong morbidities especially as TBI in early life can affect developmental processes such as puberty. One common finding in both adult and pediatric TBI patients is post-TBI-endocrine disruptions. These endocrine disruptions can lead to a long-term change in the release and regulation of hormones which is critical in childhood both before and during puberty. Indeed, post-TBI pubertal disruptions, such as precocious puberty or delayed puberty, have been described in the TBI literature. This chapter outlines post-TBI pubertal dysfunctions with a focus on how hormones are affected after TBI.

Original languageEnglish
Title of host publicationCellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury
PublisherElsevier
Chapter29
Pages351-362
Number of pages12
ISBN (Electronic)9780128230367
ISBN (Print)9780128230602
DOIs
Publication statusPublished - 1 Jan 2022
Externally publishedYes

Keywords

  • Delayed puberty
  • Estrogen
  • Follicle-stimulating hormone
  • Gonadotropin-releasing hormone
  • Growth hormone
  • Hypothalamic-pituitary-gonadal axis
  • Luteinizing hormone
  • Precocious puberty
  • Testosterone

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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