Abstract
Traumatic brain injuries (TBI) in children are a leading cause of death and disability worldwide. Individuals who survive pediatric TBI can be left with lifelong morbidities especially as TBI in early life can affect developmental processes such as puberty. One common finding in both adult and pediatric TBI patients is post-TBI-endocrine disruptions. These endocrine disruptions can lead to a long-term change in the release and regulation of hormones which is critical in childhood both before and during puberty. Indeed, post-TBI pubertal disruptions, such as precocious puberty or delayed puberty, have been described in the TBI literature. This chapter outlines post-TBI pubertal dysfunctions with a focus on how hormones are affected after TBI.
Original language | English |
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Title of host publication | Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury |
Publisher | Elsevier |
Chapter | 29 |
Pages | 351-362 |
Number of pages | 12 |
ISBN (Electronic) | 9780128230367 |
ISBN (Print) | 9780128230602 |
DOIs | |
Publication status | Published - 1 Jan 2022 |
Externally published | Yes |
Keywords
- Delayed puberty
- Estrogen
- Follicle-stimulating hormone
- Gonadotropin-releasing hormone
- Growth hormone
- Hypothalamic-pituitary-gonadal axis
- Luteinizing hormone
- Precocious puberty
- Testosterone
ASJC Scopus subject areas
- General Medicine
- General Neuroscience