Pt/C catalysed direct reductive amination of nitriles with primary amines in a continuous flow multichannel microreactor

S.K. Sharma; J. Lynch; A.M. Sobolewska; P. Plucinski; R.J. Watson; Jonathan M J Williams

doi:10.1039/c2cy20431b

Pt/C catalysed direct reductive amination of nitriles with primary amines in a continuous flow multichannel microreactor

S.K. Sharma, J. Lynch, A.M. Sobolewska, P. Plucinski, R.J. Watson, Jonathan M J Williams

GlaxoSmithKline

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Abstract

Aliphatic and aromatic secondary amines were synthesised selectively by one pot reductive amination of nitriles with primary amines using Pt/C (3% by weight) catalyst in a continuous flow multichannel microreactor. Molecular hydrogen was used as a clean reducing agent at moderate reaction conditions.

Original language	English
Pages (from-to)	85-88
Number of pages	4
Journal	Catalysis Science and Technology
Volume	3
Issue number	1
Early online date	1 Nov 2012
DOIs	https://doi.org/10.1039/c2cy20431b
Publication status	Published - 2013

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10.1039/c2cy20431b

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title = "Pt/C catalysed direct reductive amination of nitriles with primary amines in a continuous flow multichannel microreactor",

abstract = "Aliphatic and aromatic secondary amines were synthesised selectively by one pot reductive amination of nitriles with primary amines using Pt/C (3\% by weight) catalyst in a continuous flow multichannel microreactor. Molecular hydrogen was used as a clean reducing agent at moderate reaction conditions. ",

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AU - Sharma, S.K.

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AU - Sobolewska, A.M.

AU - Plucinski, P.

AU - Watson, R.J.

AU - Williams, Jonathan M J

PY - 2013

Y1 - 2013

N2 - Aliphatic and aromatic secondary amines were synthesised selectively by one pot reductive amination of nitriles with primary amines using Pt/C (3% by weight) catalyst in a continuous flow multichannel microreactor. Molecular hydrogen was used as a clean reducing agent at moderate reaction conditions.

AB - Aliphatic and aromatic secondary amines were synthesised selectively by one pot reductive amination of nitriles with primary amines using Pt/C (3% by weight) catalyst in a continuous flow multichannel microreactor. Molecular hydrogen was used as a clean reducing agent at moderate reaction conditions.

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Pt/C catalysed direct reductive amination of nitriles with primary amines in a continuous flow multichannel microreactor

Abstract

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Pt/C catalysed direct reductive amination of nitriles with primary amines in a continuous flow multichannel microreactor

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