Psoriatic arthritis

clinical subgroups and histocompatibility antigens

N J McHugh, M R Laurent, B L Treadwell, J M Tweed, J Dagger

Research output: Contribution to journalArticle

Abstract

Histocompatibility antigens were determined in 60 patients with psoriatic arthritis. The patients were divided into clinical subgroups according to axial or peripheral joint involvement, disease severity based on number of peripheral joints involved, and the presence or absence of bone erosions. The total group showed a significant increase in frequency of HLA-A1, B17, B27, and DR7 when compared with a control population. The subgroup with spondylitis had a significant increase in frequency of HLA-B27 when compared with patients with peripheral arthritis (p less than 0.001). The subgroup with peripheral arthritis alone had a higher frequency of HLA-DR7 than the control group (p less than 0.001). There were also significant associations between HLA-DR7 and chronic severe disease (p less than 0.001) and between HLA-DR4 and the presence of erosions (p less than 0.05).
Original languageEnglish
Pages (from-to)184-8
Number of pages5
JournalAnnals of the Rheumatic Diseases
Volume46
Issue number3
DOIs
Publication statusPublished - Mar 1987

Fingerprint

HLA-DR7 Antigen
Psoriatic Arthritis
Histocompatibility Antigens
Erosion
HLA-A1 Antigen
HLA-DR4 Antigen
HLA-B27 Antigen
Arthritis
Spondylitis
Bone
Joint Diseases
Chronic Disease
Joints
Bone and Bones
Control Groups
Population

Keywords

  • Arthritis
  • Female
  • HLA Antigens
  • Humans
  • Male
  • Psoriasis

Cite this

Psoriatic arthritis : clinical subgroups and histocompatibility antigens. / McHugh, N J; Laurent, M R; Treadwell, B L; Tweed, J M; Dagger, J.

In: Annals of the Rheumatic Diseases, Vol. 46, No. 3, 03.1987, p. 184-8.

Research output: Contribution to journalArticle

McHugh, N J ; Laurent, M R ; Treadwell, B L ; Tweed, J M ; Dagger, J. / Psoriatic arthritis : clinical subgroups and histocompatibility antigens. In: Annals of the Rheumatic Diseases. 1987 ; Vol. 46, No. 3. pp. 184-8.
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