Pseudomonas aeruginosa’s adaptive trajectory: diverse origins, convergent paths

Tiffany Taylor; Matthew J. Shepherd; James Horton

doi:10.1016/j.tim.2023.12.002

Pseudomonas aeruginosa’s adaptive trajectory: diverse origins, convergent paths

Tiffany Taylor
, Matthew J. Shepherd
, James Horton

University of Manchester

Research output: Contribution to journal › Article › peer-review

1 Citation (SciVal)

Abstract

Does genetic background contribute to populations following the same or divergent adaptive trajectories? A recent study by Filipow et al. evolved multiple genetically distinct Pseudomonas aeruginosa strains to an artificial cystic fibrosis lung sputum media. The strains adapted at different rates but converged on similar phenotypes despite their initial diversity.

Original language	English
Number of pages	3
Journal	Trends in Microbiology
Early online date	14 Dec 2023
DOIs	https://doi.org/10.1016/j.tim.2023.12.002
Publication status	Published - 14 Dec 2023

Funding

T.B.T. is supported by a Royal Society Dorothy Hodgkin Research Fellowship (RG160491), J.S.H. is supported by a BBSRC NI grant (BB/T012994/1) and M.J.S. is supported by a Wellcome Trust Grant (220243/Z/20/Z).

Funders	Funder number
BBSRC NI	BB/T012994/1
The Wellcome Trust	220243/Z/20/Z
Royal Society	RG160491

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

contingency
epistasis
experimental evolution
fitness landscape
trait value

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Virology
Microbiology

Access to Document

10.1016/j.tim.2023.12.002Licence: CC BY

https://www.cell.com/action/showPdf?pii=S0966-842X%2823%2900337-2Licence: CC BY

Cite this

@article{45e08a4842b345bfb2b4f88dc51829b7,

title = "Pseudomonas aeruginosa{\textquoteright}s adaptive trajectory: diverse origins, convergent paths",

abstract = "Does genetic background contribute to populations following the same or divergent adaptive trajectories? A recent study by Filipow et al. evolved multiple genetically distinct Pseudomonas aeruginosa strains to an artificial cystic fibrosis lung sputum media. The strains adapted at different rates but converged on similar phenotypes despite their initial diversity.",

keywords = "contingency, epistasis, experimental evolution, fitness landscape, trait value",

author = "Tiffany Taylor and Shepherd, \{Matthew J.\} and James Horton",

year = "2023",

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T2 - diverse origins, convergent paths

AU - Taylor, Tiffany

AU - Shepherd, Matthew J.

AU - Horton, James

PY - 2023/12/14

Y1 - 2023/12/14

N2 - Does genetic background contribute to populations following the same or divergent adaptive trajectories? A recent study by Filipow et al. evolved multiple genetically distinct Pseudomonas aeruginosa strains to an artificial cystic fibrosis lung sputum media. The strains adapted at different rates but converged on similar phenotypes despite their initial diversity.

AB - Does genetic background contribute to populations following the same or divergent adaptive trajectories? A recent study by Filipow et al. evolved multiple genetically distinct Pseudomonas aeruginosa strains to an artificial cystic fibrosis lung sputum media. The strains adapted at different rates but converged on similar phenotypes despite their initial diversity.

KW - contingency

KW - epistasis

KW - experimental evolution

KW - fitness landscape

KW - trait value

UR - https://www.scopus.com/pages/publications/85180328889

U2 - 10.1016/j.tim.2023.12.002

DO - 10.1016/j.tim.2023.12.002

M3 - Article

SN - 0966-842X

JO - Trends in Microbiology

JF - Trends in Microbiology

ER -

Pseudomonas aeruginosa’s adaptive trajectory: diverse origins, convergent paths

Abstract

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Predicting evolution: using comparative experimental evolution to test the role of mutation, selection and genetic background on repeatable evolution

Cite this

Pseudomonas aeruginosa’s adaptive trajectory: diverse origins, convergent paths

Abstract

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Predicting evolution: using comparative experimental evolution to test the role of mutation, selection and genetic background on repeatable evolution

Cite this