Proteins on the catwalk: modelling the structural domains of the CCN family of proteins

Kenneth P. Holbourn, Bernard Perbal, K. Ravi Acharya

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The CCN family of proteins (CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6) are multifunctional mosaic proteins that play keys roles in crucial areas of physiology such as angiogenesis, skeletal development tumourigenesis, cell proliferation, adhesion and survival. This expansive repertoire of functions comes through a modular structure of 4 discrete domains that act both independently and in concert. How these interactions with ligands and with neighbouring domains lead to the biological effects is still to be explored but the molecular structure of the domains is likely to play an important role in this. In this review we have highlighted some of the key features of the individual domains of CCN family of proteins based on their biological effects using a homology modelling approach.
Original languageEnglish
Pages (from-to)25-41
Number of pages17
JournalJournal of Cell Communication and Signaling
Volume3
Issue number1
DOIs
Publication statusPublished - Mar 2009

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