Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

Stephane Peluso, Pascal Dumy, Ian Eggleston, Patrick Garrouste, Manfred Mutter

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic.
Original languageEnglish
Pages (from-to)7231-7236
JournalTetrahedron
Volume53
Issue number21
DOIs
Publication statusPublished - 1997

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