Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

Stephane  Peluso; Pascal Dumy; Ian Eggleston; Patrick Garrouste; Manfred Mutter

doi:10.1016/S0040-4020(97)00408-0

Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

Stephane Peluso, Pascal Dumy, Ian Eggleston, Patrick Garrouste, Manfred Mutter

Department of Life Sciences

University of Lausanne

Research output: Contribution to journal › Article › peer-review

12 Citations (SciVal)

Abstract

The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic.

Original language	English
Pages (from-to)	7231-7236
Journal	Tetrahedron
Volume	53
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4020(97)00408-0
Publication status	Published - 1997

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title = "Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template",

abstract = "The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic.",

author = "Stephane Peluso and Pascal Dumy and Ian Eggleston and Patrick Garrouste and Manfred Mutter",

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T1 - Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

AU - Peluso, Stephane

AU - Dumy, Pascal

AU - Eggleston, Ian

AU - Garrouste, Patrick

AU - Mutter, Manfred

PY - 1997

Y1 - 1997

N2 - The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic.

AB - The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic.

UR - http://dx.doi.org/10.1016/S0040-4020(97)00408-0

U2 - 10.1016/S0040-4020(97)00408-0

DO - 10.1016/S0040-4020(97)00408-0

M3 - Article

SN - 0040-4020

VL - 53

SP - 7231

EP - 7236

JO - Tetrahedron

JF - Tetrahedron

IS - 21

ER -

Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template

Abstract

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