Protein arginine methylation: a new handle on T lymphocytes?

Richard V Parry, S G Ward

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Protein arginine methylation has emerged as a key regulator of signal transduction with an important role in T lymphocyte activation. The predominant methyl transferase PRMT-1 is highly expressed in T helper cells, and ligation of the T cell antigen and costimulatory receptors, induces arginine methylation on several cytoplasmic proteins. Global inhibition of methyl transferases can result in signaling defects in CD4 T cells and profound immunosuppression. Here we suggest that manipulating protein arginine methylation could be a feasible strategy to modulate T lymphocyte function, presenting a novel approach towards immunotherapy and the treatment of T cell-mediated disorders such as autoimmune disease and transplant rejection.
Original languageEnglish
Pages (from-to)164-169
Number of pages6
JournalTrends in Immunology
Volume31
Issue number4
DOIs
Publication statusPublished - 2010

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