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Abstract
Glucagon-like peptide-1 (GLP-1) is an incretin hormone produced in the intestine which is secreted in response to nutrient exposure. GLP-1 potentiates glucose-dependent insulin secretion from the pancreatic beta cells and promotes satiety. These important actions on glucose metabolism and appetite have led to widespread interest in GLP-1 receptor agonism. Typically, this involves pharmacological GLP-1 mimetics or targeted inhibition of dipeptidyl peptidase 4 (DPP4), the enzyme responsible for GLP-1 degradation. However, nutritional strategies provide a widely available, cost-effective alternative to pharmacological strategies for enhancing hormone release. Recent advances in nutritional research have implicated the combined ingestion of protein and calcium with enhanced endogenous GLP-1 release, which is likely due to activation of receptors with high affinity and/or sensitivity for amino acids and calcium. Specifically targeting these receptors may enhance gut hormone secretion, thus providing a new therapeutic option. This narrative review provides an overview of the latest research on protein and calcium mediated GLP-1 release with an emphasis on human data, and a perspective on potential mechanisms that link potent GLP-1 release to the co-ingestion of protein and calcium. In light of these recent findings, potential future research directions are also presented.
Original language | English |
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Pages (from-to) | 2540–2552 |
Number of pages | 13 |
Journal | Advances in nutrition (Bethesda, Md.) |
Volume | 12 |
Issue number | 6 |
Early online date | 30 Jun 2021 |
DOIs | |
Publication status | Published - 1 Nov 2021 |
Bibliographical note
Publisher Copyright:© 2021 The Author(s). Published by Oxford University Press on behalf of the American Society for Nutrition.
Keywords
- GLP-1
- calcium
- extracellular calcium-sensing receptor
- metabolic regulation
- protein
- type 2 diabetes
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
- Nutrition and Dietetics
Fingerprint
Dive into the research topics of 'Protein- A nd Calcium-Mediated GLP-1 Secretion: A Narrative Review'. Together they form a unique fingerprint.Projects
- 1 Finished
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Role of Rab3 in Peripheral Tissue Insulin Resistance
Koumanov, F. (PI), Betts, J. (CoI), Gonzalez, J. (CoI), Thompson, D. (CoI) & Whitley, P. (CoI)
1/12/16 → 31/07/20
Project: Research council