Pros and cons of methods used for the prediction of oral drug absorption

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8 Citations (Scopus)

Abstract

Oral drug administration can be problematic owing to the specific physicochemical characteristics of new chemical entities. Assessment of the possibility of a new active compound to be administered orally, as well as of the requirements for a successful oral administration (type of dosage form, dosing conditions), constitute a substantial burden during the drug-discovery and drug-development process. Throughout drug development, in silico, in vitro, in vivo and integrated dynamic models play an important role for the decision making in absorption-related issues. In this review, the most common methods used for the prediction of oral drug absorption as a stage development approach are discussed.
Original languageEnglish
Pages (from-to)195-208
Number of pages14
JournalExpert Review of Clinical Pharmacology
Volume2
Issue number2
DOIs
Publication statusPublished - 2009

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