TY - JOUR
T1 - Pros and cons of methods used for the prediction of oral drug absorption
AU - Fotaki, Nikoletta
PY - 2009
Y1 - 2009
N2 - Oral drug administration can be problematic owing to the specific physicochemical characteristics of new chemical entities. Assessment of the possibility of a new active compound to be administered orally, as well as of the requirements for a successful oral administration (type of dosage form, dosing conditions), constitute a substantial burden during the drug-discovery and drug-development process. Throughout drug development, in silico, in vitro, in vivo and integrated dynamic models play an important role for the decision making in absorption-related issues. In this review, the most common methods used for the prediction of oral drug absorption as a stage development approach are discussed.
AB - Oral drug administration can be problematic owing to the specific physicochemical characteristics of new chemical entities. Assessment of the possibility of a new active compound to be administered orally, as well as of the requirements for a successful oral administration (type of dosage form, dosing conditions), constitute a substantial burden during the drug-discovery and drug-development process. Throughout drug development, in silico, in vitro, in vivo and integrated dynamic models play an important role for the decision making in absorption-related issues. In this review, the most common methods used for the prediction of oral drug absorption as a stage development approach are discussed.
UR - http://www.scopus.com/inward/record.url?scp=70149113223&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1586/17512433.2.2.195
U2 - 10.1586/17512433.2.2.195
DO - 10.1586/17512433.2.2.195
M3 - Article
SN - 1751-2433
VL - 2
SP - 195
EP - 208
JO - Expert Review of Clinical Pharmacology
JF - Expert Review of Clinical Pharmacology
IS - 2
ER -