TY - JOUR
T1 - Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung
AU - Licchesi, Julien D. F.
AU - Westra, William H.
AU - Hooker, Craig M.
AU - Herman, James G.
PY - 2008/5/1
Y1 - 2008/5/1
N2 - According to current models of tumorigenesis, the progression of phenotypic changes culminating in overtly malignant carcinoma is driven by genetic and epigenetic alterations. The recognition of an early form of glandular neoplasia termed atypical adenomatous hyperplasia (AAH), a precursor lesion from which lung adenocarcinomas arise, provides an opportunity for characterizing early epigenetic alterations involved in lung tumorigenesis.
AB - According to current models of tumorigenesis, the progression of phenotypic changes culminating in overtly malignant carcinoma is driven by genetic and epigenetic alterations. The recognition of an early form of glandular neoplasia termed atypical adenomatous hyperplasia (AAH), a precursor lesion from which lung adenocarcinomas arise, provides an opportunity for characterizing early epigenetic alterations involved in lung tumorigenesis.
UR - http://www.scopus.com/inward/record.url?scp=47949123984&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1158/1078-0432.CCR-07-2033
U2 - 10.1158/1078-0432.CCR-07-2033
DO - 10.1158/1078-0432.CCR-07-2033
M3 - Article
C2 - 18451218
SN - 1078-0432
VL - 14
SP - 2570
EP - 2578
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 9
ER -
