Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung

Julien D. F. Licchesi, William H. Westra, Craig M. Hooker, James G. Herman

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)

Abstract

According to current models of tumorigenesis, the progression of phenotypic changes culminating in overtly malignant carcinoma is driven by genetic and epigenetic alterations. The recognition of an early form of glandular neoplasia termed atypical adenomatous hyperplasia (AAH), a precursor lesion from which lung adenocarcinomas arise, provides an opportunity for characterizing early epigenetic alterations involved in lung tumorigenesis.
Original languageEnglish
Pages (from-to)2570-2578
Number of pages9
JournalClinical Cancer Research
Volume14
Issue number9
DOIs
Publication statusPublished - 1 May 2008

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