Processing of spherical crystalline particles via a novel solution atomization and crystallization by sonication (SAXS) technique

J. Sebastian Kaerger, Robert Price

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Purpose. The objective was to develop a single-step pharmaceutical particle engineering technique able to produce particles within a well-defined particle size range while controlling macroscopic spherical morphology and mesoscopic surface topography. Methods. Paracetamol ( acetaminophen) aerosol droplets were generated by spraying a solution via either an electrohydrodynamic atomizer ( EHDA) or an air pressure atomizer. The highly supersaturated droplets were collected in a suitable nonsolvent of the drug and crystallized by ultrasonication. Suspended particles were filtered, and their physicochemical properties characterized. Results. The SAXS processed particles showed a relatively homogeneous particle size distribution between 1 and 5 mum. Particles were nominally crystalline in structure. The chemical structure of the active ingredient did not apparently alter during processing. Controlling the solute concentration of the air pressure atomized solution provided a means of controlling the degree of sphericity and particle-size characteristics. In comparison to micronized paracetamol particles, SAXS-produced particulates were generally more uniform in shape with increased nanometer surface roughness. Conclusions. The SAXS process provides a novel means of producing crystalline particles in a well-defined particle size range. Furthermore, the method offers a range of opportunities in controlling physical properties including surface topography and particle shape.
Original languageEnglish
Pages (from-to)372-381
Number of pages10
JournalPharmaceutical Research
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2004

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Sonication
Atomization
Acetaminophen
Crystallization
Particle Size
Atomizers
Particle size
Surface topography
Crystalline materials
Air Pressure
Particles (particulate matter)
Nebulizers and Vaporizers
Processing
Electrohydrodynamics
Spraying
Air
Aerosols
Particle size analysis
Pharmaceutical Preparations
Surface Properties

Cite this

Processing of spherical crystalline particles via a novel solution atomization and crystallization by sonication (SAXS) technique. / Kaerger, J. Sebastian; Price, Robert.

In: Pharmaceutical Research, Vol. 21, No. 2, 02.2004, p. 372-381.

Research output: Contribution to journalArticle

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