TY - JOUR
T1 - Probing the Impedance of a Biological Tissue with PEDOT:PSS-Coated Metal Electrodes
T2 - Effect of Electrode Size on Sensing Efficiency
AU - Koutsouras, Dimitrios A.
AU - Lingstedt, Leona V.
AU - Lieberth, Katharina
AU - Reinholz, Jonas
AU - Mailänder, Volker
AU - Blom, Paul W.M.
AU - Gkoupidenis, Paschalis
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Electrodes coated with poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) have been employed to measure the integrity of cellular barriers. However, a systematic experimental study of the correlation between tissue integrity and impedance of the sensing device has not yet been conducted. Using impedance spectroscopy, how the impedance ratio of the biological tissue to the recording device affects the recording ability of the latter is investigated. PEDOT:PSS-coated electrodes of various dimensions are employed and the effect of their size to their sensing efficiency is examined. The biotic/abiotic ensemble is modeled with a simple equivalent circuit and an analytical expression of the total impedance as a function of frequency is extracted. The results reveal a critical impedance ratio of the biological tissue to the sensor which allows for efficient sensing of the tissue integrity. This work provides the ground rules for improved impedance-based biosensors with optimized sensitivity.
AB - Electrodes coated with poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) have been employed to measure the integrity of cellular barriers. However, a systematic experimental study of the correlation between tissue integrity and impedance of the sensing device has not yet been conducted. Using impedance spectroscopy, how the impedance ratio of the biological tissue to the recording device affects the recording ability of the latter is investigated. PEDOT:PSS-coated electrodes of various dimensions are employed and the effect of their size to their sensing efficiency is examined. The biotic/abiotic ensemble is modeled with a simple equivalent circuit and an analytical expression of the total impedance as a function of frequency is extracted. The results reveal a critical impedance ratio of the biological tissue to the sensor which allows for efficient sensing of the tissue integrity. This work provides the ground rules for improved impedance-based biosensors with optimized sensitivity.
KW - biosensors
KW - impedance spectroscopy
KW - PEDOT:PSS sensors
UR - http://www.scopus.com/inward/record.url?scp=85074883077&partnerID=8YFLogxK
U2 - 10.1002/adhm.201901215
DO - 10.1002/adhm.201901215
M3 - Article
C2 - 31701673
AN - SCOPUS:85074883077
SN - 2192-2640
VL - 8
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 23
M1 - 1901215
ER -