Probing disease-related proteins with fluorogenic composite materials

Xiao Peng He, Yi Zang, Tony D. James, Jia Li, Guo Rong Chen

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

Construction of composite materials based on the self-assembly of fluorescently labeled biomolecules with a variety of micro- or nano-quenching materials (by the Förster Resonance Energy Transfer mechanism) for the fluorogenic recognition of disease-related proteins has become a dynamic research topic in the field of fluorescence recognition. Here we summarize the recent progress on the composition of fluorescence dye-labeled biomolecules including sugars, peptides and nucleotides with organic (graphene and carbon nanotubes) and inorganic (gold nanoparticles) materials. Their application in the fluorescence detection of proteins and enzymes on both the molecular and cellular levels is discussed. Perspectives are proposed with respect to the future directions of employing these composite materials in the recognition of pathological proteins.

Original languageEnglish
Pages (from-to)4239-4248
Number of pages10
JournalChemical Society Reviews
Volume44
Issue number13
DOIs
Publication statusPublished - 7 Jul 2015

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Fluorescence
Biomolecules
Quenching
Composite materials
Carbon Nanotubes
Proteins
Graphite
Sugars
Gold
Energy transfer
Self assembly
Coloring Agents
Nucleotides
Nanoparticles
Peptides
Enzymes
Chemical analysis
Direction compound

Cite this

Probing disease-related proteins with fluorogenic composite materials. / He, Xiao Peng; Zang, Yi; James, Tony D.; Li, Jia; Chen, Guo Rong.

In: Chemical Society Reviews, Vol. 44, No. 13, 07.07.2015, p. 4239-4248.

Research output: Contribution to journalReview article

He, Xiao Peng ; Zang, Yi ; James, Tony D. ; Li, Jia ; Chen, Guo Rong. / Probing disease-related proteins with fluorogenic composite materials. In: Chemical Society Reviews. 2015 ; Vol. 44, No. 13. pp. 4239-4248.
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