Probing disaccharide selectivity with modular fluorescent sensors

Susumu Arimori; Marcus D Phillips; Tony D James

doi:10.1016/j.tetlet.2003.12.013

Probing disaccharide selectivity with modular fluorescent sensors

Susumu Arimori, Marcus D Phillips, Tony D James

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

36 Citations (SciVal)

Abstract

Six modular photoinduced electron transfer (PET) sensors bearing two phenylboronic acid receptors have been evaluated as fluorescent disaccharide sensors. The length of linker separating the two boronic acid moieties was varied and the sensors' interaction with disaccharides assessed via fluorescence spectroscopy. It was shown that saccharide selectivity was influenced by the choice of linker length. Diboronic acid sensors 3(n) also displayed significant specificity for the disaccharides linked to the carbon on the 3rd or 6th position (as numbered from the anomeric centre) over those linked at the 4th position.

Original language	English
Pages (from-to)	1539-1542
Number of pages	4
Journal	Tetrahedron Letters
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/j.tetlet.2003.12.013
Publication status	Published - 2004

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title = "Probing disaccharide selectivity with modular fluorescent sensors",

abstract = "Six modular photoinduced electron transfer (PET) sensors bearing two phenylboronic acid receptors have been evaluated as fluorescent disaccharide sensors. The length of linker separating the two boronic acid moieties was varied and the sensors' interaction with disaccharides assessed via fluorescence spectroscopy. It was shown that saccharide selectivity was influenced by the choice of linker length. Diboronic acid sensors 3(n) also displayed significant specificity for the disaccharides linked to the carbon on the 3rd or 6th position (as numbered from the anomeric centre) over those linked at the 4th position.",

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AU - James, Tony D

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AB - Six modular photoinduced electron transfer (PET) sensors bearing two phenylboronic acid receptors have been evaluated as fluorescent disaccharide sensors. The length of linker separating the two boronic acid moieties was varied and the sensors' interaction with disaccharides assessed via fluorescence spectroscopy. It was shown that saccharide selectivity was influenced by the choice of linker length. Diboronic acid sensors 3(n) also displayed significant specificity for the disaccharides linked to the carbon on the 3rd or 6th position (as numbered from the anomeric centre) over those linked at the 4th position.

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DO - 10.1016/j.tetlet.2003.12.013

M3 - Article

SN - 0040-4039

VL - 45

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EP - 1542

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 7

ER -

Probing disaccharide selectivity with modular fluorescent sensors

Abstract

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