Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I2 ligand

Philippa A. Coates; Peter Grundt; Emma S.J. Robinson; David J. Nutt; Robin Tyacke; Alan L. Hudson; John W. Lewis; Stephen M. Husbands

doi:10.1016/S0960-894X(00)00062-7

Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I₂ ligand

Philippa A. Coates, Peter Grundt, Emma S.J. Robinson, David J. Nutt, Robin Tyacke, Alan L. Hudson, John W. Lewis, Stephen M. Husbands

University of Bristol

Research output: Contribution to journal › Article › peer-review

17 Citations (SciVal)

Abstract

An irreversible ligand (7) has been prepared based on the selective I₂ ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I₂-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I₂-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	605-607
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(00)00062-7
Publication status	Published - 20 Mar 2000

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00062-7

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abstract = "An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.",

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AU - Coates, Philippa A.

AU - Grundt, Peter

AU - Robinson, Emma S.J.

AU - Nutt, David J.

AU - Tyacke, Robin

AU - Hudson, Alan L.

AU - Lewis, John W.

AU - Husbands, Stephen M.

PY - 2000/3/20

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AB - An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.

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IS - 6

ER -

Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I₂ ligand

Abstract

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