Probes for imidazoline binding sites: Synthesis and evaluation of a selective, irreversible I2 ligand

Philippa A. Coates, Peter Grundt, Emma S.J. Robinson, David J. Nutt, Robin Tyacke, Alan L. Hudson, John W. Lewis, Stephen M. Husbands

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)605-607
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number6
DOIs
Publication statusPublished - 20 Mar 2000

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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