Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates

Pak-Leung Ho; Lai-Ming Leung; Kin-Hung Chow; Eileen L Lai; Wai-U Lo; Tak-Keung Ng

doi:10.1016/j.jmii.2014.08.012

Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates

Pak-Leung Ho, Lai-Ming Leung, Kin-Hung Chow, Eileen L Lai, Wai-U Lo, Tak-Keung Ng

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (SciVal)

Abstract

Aminoglycoside resistance determinants among 188 aminoglycoside-resistant blood culture Escherichia coli isolates from a tertiary hospital in Hong Kong, from 2004 to 2010 were investigated. Overall, 91% had aac(3)-II, 12.2% had aac(6')-Ib/Ib-cr, and 5.4% had the methylase genes (rmtB, armA). Aminoglycoside-resistant isolates with aac(')-Ib/Ib-cr, rmtB, and armA often had coresistance to multiple other antibiotics.

Original language	English
Pages (from-to)	123-6
Number of pages	4
Journal	Journal of Microbiology, Immunology and Infection = Wei mian yu gan ran za zhi
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.jmii.2014.08.012
Publication status	Published - 1 Feb 2016

Bibliographical note

Keywords

Acetyltransferases/genetics
Aminoglycosides/pharmacology
Anti-Bacterial Agents/pharmacology
Drug Resistance, Bacterial
Escherichia coli/drug effects
Escherichia coli Infections/microbiology
Hong Kong
Humans
Prevalence
Tertiary Care Centers
tRNA Methyltransferases/genetics

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Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates. / Ho, Pak-Leung; Leung, Lai-Ming; Chow, Kin-Hung et al.
In: Journal of Microbiology, Immunology and Infection = Wei mian yu gan ran za zhi, Vol. 49, No. 1, 01.02.2016, p. 123-6.

Research output: Contribution to journal › Article › peer-review

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title = "Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates",

abstract = "Aminoglycoside resistance determinants among 188 aminoglycoside-resistant blood culture Escherichia coli isolates from a tertiary hospital in Hong Kong, from 2004 to 2010 were investigated. Overall, 91% had aac(3)-II, 12.2% had aac(6')-Ib/Ib-cr, and 5.4% had the methylase genes (rmtB, armA). Aminoglycoside-resistant isolates with aac(')-Ib/Ib-cr, rmtB, and armA often had coresistance to multiple other antibiotics.",

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author = "Pak-Leung Ho and Lai-Ming Leung and Kin-Hung Chow and Lai, {Eileen L} and Wai-U Lo and Tak-Keung Ng",

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AU - Leung, Lai-Ming

AU - Chow, Kin-Hung

AU - Lai, Eileen L

AU - Lo, Wai-U

AU - Ng, Tak-Keung

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AB - Aminoglycoside resistance determinants among 188 aminoglycoside-resistant blood culture Escherichia coli isolates from a tertiary hospital in Hong Kong, from 2004 to 2010 were investigated. Overall, 91% had aac(3)-II, 12.2% had aac(6')-Ib/Ib-cr, and 5.4% had the methylase genes (rmtB, armA). Aminoglycoside-resistant isolates with aac(')-Ib/Ib-cr, rmtB, and armA often had coresistance to multiple other antibiotics.

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KW - Aminoglycosides/pharmacology

KW - Anti-Bacterial Agents/pharmacology

KW - Drug Resistance, Bacterial

KW - Escherichia coli/drug effects

KW - Escherichia coli Infections/microbiology

KW - Hong Kong

KW - Humans

KW - Prevalence

KW - Tertiary Care Centers

KW - tRNA Methyltransferases/genetics

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IS - 1

ER -

Prevalence of aminoglycoside modifying enzyme and 16S ribosomal RNA methylase genes among aminoglycoside-resistant Escherichia coli isolates

Abstract

Bibliographical note

Keywords

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