Predictive models for oral drug absorption: From in silico methods to integrated dynamical models

Aristides Dokoumetzidis, Lida Kalantzi, Nikoletta Fotaki

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Poor oral absorption is one of the most common reasons for a drug to be terminated during development. Oral drug absorption is a complex process affected by many competing factors related to the compound, the formulation and the gastrointestinal physiology. Throughout drug development, in silico, computational and mathematical models play important roles in the support of drug development and decision making in absorption-related issues. These models range from simple empirical rule of thumb tools to sophisticated dynamic systems. This article reviews the different computational methods for oral drug absorption for the various processes, with emphasis on solubility, permeability, dissolution and release rates, and gastrointestinal transit, but also on the modern integrated absorption prediction systems and computer software.

Original languageEnglish
Pages (from-to)491-505
Number of pages15
JournalExpert Opinion Drug Metabolism and Toxicology
Volume3
Issue number4
DOIs
Publication statusPublished - 2007

Keywords

  • Drug dissolution
  • Intestinal transit
  • Permeability
  • Solubility

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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