Predictive and prognostic value of non-coding RNA in breast cancer

Navid Sobhani; Richard  Chahwan; Raheleh  Roudi; Rachel Morris; Stefano Volinia; Dafei Chai; Alberto D'Angelo; Daniele Generali

doi:10.3390/cancers14122952

Predictive and prognostic value of non-coding RNA in breast cancer

Navid Sobhani, Richard Chahwan, Raheleh Roudi, Rachel Morris, Stefano Volinia, Dafei Chai, Alberto D'Angelo, Daniele Generali

Department of Life Sciences

Research output: Contribution to journal › Review article › peer-review

13 Citations (SciVal)

Abstract

For decades since the central dogma, cancer biology research has been focusing on the involvement of genes encoding proteins. It has been not until more recent times that a new molecular class has been discovered, named non-coding RNA (ncRNA), which has been shown to play crucial roles in shaping the activity of cells. An extraordinary number of studies has shown that ncRNAs represent an extensive and prevalent group of RNAs, including both oncogenic or tumor suppressive molecules. Henceforth, various clinical trials involving ncRNAs as extraordinary biomarkers or therapies have started to emerge. In this review, we will focus on the prognostic and diagnostic role of ncRNAs for breast cancer.

Original language	English
Article number	2952
Journal	Cancers
Volume	14
Issue number	12
DOIs	https://doi.org/10.3390/cancers14122952
Publication status	Published - 15 Jun 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

biomarkers
breast cancer
diagnostic
non-coding RNA
prognostic

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers14122952Licence: CC BY

Cite this

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abstract = "For decades since the central dogma, cancer biology research has been focusing on the involvement of genes encoding proteins. It has been not until more recent times that a new molecular class has been discovered, named non-coding RNA (ncRNA), which has been shown to play crucial roles in shaping the activity of cells. An extraordinary number of studies has shown that ncRNAs represent an extensive and prevalent group of RNAs, including both oncogenic or tumor suppressive molecules. Henceforth, various clinical trials involving ncRNAs as extraordinary biomarkers or therapies have started to emerge. In this review, we will focus on the prognostic and diagnostic role of ncRNAs for breast cancer.",

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T1 - Predictive and prognostic value of non-coding RNA in breast cancer

AU - Sobhani, Navid

AU - Chahwan, Richard

AU - Roudi, Raheleh

AU - Morris, Rachel

AU - Volinia, Stefano

AU - Chai, Dafei

AU - D'Angelo, Alberto

AU - Generali, Daniele

PY - 2022/6/15

Y1 - 2022/6/15

N2 - For decades since the central dogma, cancer biology research has been focusing on the involvement of genes encoding proteins. It has been not until more recent times that a new molecular class has been discovered, named non-coding RNA (ncRNA), which has been shown to play crucial roles in shaping the activity of cells. An extraordinary number of studies has shown that ncRNAs represent an extensive and prevalent group of RNAs, including both oncogenic or tumor suppressive molecules. Henceforth, various clinical trials involving ncRNAs as extraordinary biomarkers or therapies have started to emerge. In this review, we will focus on the prognostic and diagnostic role of ncRNAs for breast cancer.

AB - For decades since the central dogma, cancer biology research has been focusing on the involvement of genes encoding proteins. It has been not until more recent times that a new molecular class has been discovered, named non-coding RNA (ncRNA), which has been shown to play crucial roles in shaping the activity of cells. An extraordinary number of studies has shown that ncRNAs represent an extensive and prevalent group of RNAs, including both oncogenic or tumor suppressive molecules. Henceforth, various clinical trials involving ncRNAs as extraordinary biomarkers or therapies have started to emerge. In this review, we will focus on the prognostic and diagnostic role of ncRNAs for breast cancer.

KW - biomarkers

KW - breast cancer

KW - diagnostic

KW - non-coding RNA

KW - prognostic

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U2 - 10.3390/cancers14122952

DO - 10.3390/cancers14122952

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JF - Cancers

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Predictive and prognostic value of non-coding RNA in breast cancer

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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