Predictive and prognostic value of non-coding RNA in breast cancer

Navid Sobhani, Richard Chahwan, Raheleh Roudi, Rachel Morris, Stefano Volinia, Dafei Chai, Alberto D'Angelo, Daniele Generali

Research output: Contribution to journalReview articlepeer-review

Abstract

For decades since the central dogma, cancer biology research has been focusing on the involvement of genes encoding proteins. It has been not until more recent times that a new molecular class has been discovered, named non-coding RNA (ncRNA), which has been shown to play crucial roles in shaping the activity of cells. An extraordinary number of studies has shown that ncRNAs represent an extensive and prevalent group of RNAs, including both oncogenic or tumor suppressive molecules. Henceforth, various clinical trials involving ncRNAs as extraordinary biomarkers or therapies have started to emerge. In this review, we will focus on the prognostic and diagnostic role of ncRNAs for breast cancer.
Original languageEnglish
Article number2952
JournalCancers
Volume14
Issue number12
DOIs
Publication statusPublished - 15 Jun 2022

Keywords

  • biomarkers
  • breast cancer
  • diagnostic
  • non-coding RNA
  • prognostic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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