Label-free electrical detection of protein interactions has been achieved by direct measurement of variations in open circuit potential using an accurate differential voltage measurement as well as field-effect transistors. Our model system involves a panel of peptide aptamers that recognise specific protein partners of the cyclin-dependent kinase family, which are relevant to cancer research applications.
Estrela, P., Paul, D., Migliorato, P., Ko Ferrigno, P., Wang, L., & Huq, E. (2008). Potentiometric detection of protein interactions with peptide aptamers. In Proceedings of IEEE SENSORS 2008 Conference (pp. 646-649). IEEE. https://doi.org/10.1109/ICSENS.2008.4716524