Potential neuroprotective actions of dietary flavonoids

David Vazour, Marcus Rattray, Robert J Williams, Jeremy Spencer

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Flavonoids exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning, and cognitive function. These effects appear to be underpinned by their interaction with critical protein and lipid kinase signaling cascades in the brain leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and synaptic plasticity. Through these mechanisms, the consumption of flavonoid-rich foods throughout life holds the potential to limit neurodegeneration, decrease neuroinflammation, and prevent or reverse age-dependent loses in cognitive performance. The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develo
Original languageEnglish
Title of host publicationHandbook of Natural Products
Subtitle of host publicationNatural Products
EditorsKishan G Ramawat, Jean-Michel Merillion
PublisherSpringer
Pages2617-2640
ISBN (Print)978-3-642-22143-9
DOIs
Publication statusPublished - 1 Jan 2013

Fingerprint Dive into the research topics of 'Potential neuroprotective actions of dietary flavonoids'. Together they form a unique fingerprint.

  • Cite this

    Vazour, D., Rattray, M., Williams, R. J., & Spencer, J. (2013). Potential neuroprotective actions of dietary flavonoids. In K. G. Ramawat, & J-M. Merillion (Eds.), Handbook of Natural Products: Natural Products (pp. 2617-2640). Springer. https://doi.org/10.1007/978-3-642-22144-6_71