Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

E Walton, D P Hibar, T G M van Erp, S G Potkin, R Roiz-Santiañez, B Crespo-Facorro, P Suarez-Pinilla, N E M Van Haren, S M C de Zwarte, R S Kahn, W Cahn, N T Doan, K N Jørgensen, T P Gurholt, I Agartz, O A Andreassen, L T Westlye, I Melle, A O Berg, L Mørch-JohnsenA Faerden, L Flyckt, H Fatouros-Bergman, E G Jönsson, R Hashimoto, H Yamamori, M Fukunaga, A Preda, P De Rossi, F Piras, N Banaj, V Ciullo, G Spalletta, R E Gur, R C Gur, D H Wolf, T D Satterthwaite, L M Beard, I E Sommer, S Koops, O Gruber, A Richter, B Krämer, G Donohoe, D M Cannon, A Corvin, A Di Giorgio, A Bertolino, S Lawrie, Karolinska Schizophrenia Project Consortium (KaSP)

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

OBJECTIVE: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.METHOD: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.RESULTS: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = -0.052; P = 0.021; right: βstd = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.CONCLUSION: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.
Original languageEnglish
Pages (from-to)439-447
Number of pages9
JournalActa Psychiatrica Scandinavica
Volume135
Issue number5
Early online date19 Dec 2016
DOIs
Publication statusPublished - May 2017

Keywords

  • Adult
  • Brain Mapping
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Prospective Studies
  • Psychiatric Status Rating Scales
  • Schizophrenia
  • Schizophrenic Psychology
  • Temporal Lobe
  • Journal Article
  • Meta-Analysis
  • Multicenter Study

Fingerprint Dive into the research topics of 'Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium'. Together they form a unique fingerprint.

Cite this