Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

E Walton; D P Hibar; T G M van Erp; S G Potkin; R Roiz-Santiañez; B Crespo-Facorro; P Suarez-Pinilla; N E M Van Haren; S M C de Zwarte; R S Kahn; W Cahn; N T Doan; K N Jørgensen; T P Gurholt; I Agartz; O A Andreassen; L T Westlye; I Melle; A O Berg; L Mørch-Johnsen; A Faerden; L Flyckt; H Fatouros-Bergman; E G Jönsson; R Hashimoto; H Yamamori; M Fukunaga; A Preda; P De Rossi; F Piras; N Banaj; V Ciullo; G Spalletta; R E Gur; R C Gur; D H Wolf; T D Satterthwaite; L M Beard; I E Sommer; S Koops; O Gruber; A Richter; B Krämer; G Donohoe; D M Cannon; A Corvin; A Di Giorgio; A Bertolino; S Lawrie; Karolinska Schizophrenia Project Consortium (KaSP)

doi:10.1111/acps.12718

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

E Walton, D P Hibar, T G M van Erp, S G Potkin, R Roiz-Santiañez, B Crespo-Facorro, P Suarez-Pinilla, N E M Van Haren, S M C de Zwarte, R S Kahn, W Cahn, N T Doan, K N Jørgensen, T P Gurholt, I Agartz, O A Andreassen, L T Westlye, I Melle, A O Berg, L Mørch-JohnsenA Faerden, L Flyckt, H Fatouros-Bergman, E G Jönsson, R Hashimoto, H Yamamori, M Fukunaga, A Preda, P De Rossi, F Piras, N Banaj, V Ciullo, G Spalletta, R E Gur, R C Gur, D H Wolf, T D Satterthwaite, L M Beard, I E Sommer, S Koops, O Gruber, A Richter, B Krämer, G Donohoe, D M Cannon, A Corvin, A Di Giorgio, A Bertolino, S Lawrie, Karolinska Schizophrenia Project Consortium (KaSP)

Department of Psychology

Research output: Contribution to journal › Article › peer-review

70 Citations (SciVal)

Abstract

OBJECTIVE: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.METHOD: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.RESULTS: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = -0.052; P = 0.021; right: βstd = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.CONCLUSION: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

Original language	English
Pages (from-to)	439-447
Number of pages	9
Journal	Acta Psychiatrica Scandinavica
Volume	135
Issue number	5
Early online date	19 Dec 2016
DOIs	https://doi.org/10.1111/acps.12718
Publication status	Published - May 2017

Bibliographical note

Keywords

Adult
Brain Mapping
Female
Humans
Magnetic Resonance Imaging
Male
Prospective Studies
Psychiatric Status Rating Scales
Schizophrenia
Schizophrenic Psychology
Temporal Lobe
Journal Article
Meta-Analysis
Multicenter Study

Access to Document

10.1111/acps.12718

https://research-information.bristol.ac.uk/en/publications/positive-symptoms-associate-with-cortical-thinning-in-the-superior-temporal-gyrus-via-the-enigma-schizophrenia-consortium(04a07d0d-f847-496a-b191-88607290e567).html

Cite this

Walton, E., Hibar, D. P., van Erp, T. G. M., Potkin, S. G., Roiz-Santiañez, R., Crespo-Facorro, B., Suarez-Pinilla, P., Van Haren, N. E. M., de Zwarte, S. M. C., Kahn, R. S., Cahn, W., Doan, N. T., Jørgensen, K. N., Gurholt, T. P., Agartz, I., Andreassen, O. A., Westlye, L. T., Melle, I., Berg, A. O., ... (KaSP), K. S. P. C. (2017). Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. Acta Psychiatrica Scandinavica, 135(5), 439-447. https://doi.org/10.1111/acps.12718

Walton, E, Hibar, DP, van Erp, TGM, Potkin, SG, Roiz-Santiañez, R, Crespo-Facorro, B, Suarez-Pinilla, P, Van Haren, NEM, de Zwarte, SMC, Kahn, RS, Cahn, W, Doan, NT, Jørgensen, KN, Gurholt, TP, Agartz, I, Andreassen, OA, Westlye, LT, Melle, I, Berg, AO, Mørch-Johnsen, L, Faerden, A, Flyckt, L, Fatouros-Bergman, H, Jönsson, EG, Hashimoto, R, Yamamori, H, Fukunaga, M, Preda, A, De Rossi, P, Piras, F, Banaj, N, Ciullo, V, Spalletta, G, Gur, RE, Gur, RC, Wolf, DH, Satterthwaite, TD, Beard, LM, Sommer, IE, Koops, S, Gruber, O, Richter, A, Krämer, B, Donohoe, G, Cannon, DM, Corvin, A, Di Giorgio, A, Bertolino, A, Lawrie, S & (KaSP), KSPC 2017, 'Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium', Acta Psychiatrica Scandinavica, vol. 135, no. 5, pp. 439-447. https://doi.org/10.1111/acps.12718

@article{0d4ebe45b65a428488be873d2b944bb4,

title = "Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium",

abstract = "OBJECTIVE: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.METHOD: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.RESULTS: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = -0.052; P = 0.021; right: βstd = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.CONCLUSION: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.",

keywords = "Adult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Prospective Studies, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Temporal Lobe, Journal Article, Meta-Analysis, Multicenter Study",

author = "E Walton and Hibar, {D P} and {van Erp}, {T G M} and Potkin, {S G} and R Roiz-Santia{\~n}ez and B Crespo-Facorro and P Suarez-Pinilla and {Van Haren}, {N E M} and {de Zwarte}, {S M C} and Kahn, {R S} and W Cahn and Doan, {N T} and J{\o}rgensen, {K N} and Gurholt, {T P} and I Agartz and Andreassen, {O A} and Westlye, {L T} and I Melle and Berg, {A O} and L M{\o}rch-Johnsen and A Faerden and L Flyckt and H Fatouros-Bergman and J{\"o}nsson, {E G} and R Hashimoto and H Yamamori and M Fukunaga and A Preda and {De Rossi}, P and F Piras and N Banaj and V Ciullo and G Spalletta and Gur, {R E} and Gur, {R C} and Wolf, {D H} and Satterthwaite, {T D} and Beard, {L M} and Sommer, {I E} and S Koops and O Gruber and A Richter and B Kr{\"a}mer and G Donohoe and Cannon, {D M} and A Corvin and {Di Giorgio}, A and A Bertolino and S Lawrie and (KaSP), {Karolinska Schizophrenia Project Consortium}",

note = "{\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2017",

month = may,

doi = "10.1111/acps.12718",

language = "English",

volume = "135",

pages = "439--447",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

AU - Walton, E

AU - Hibar, D P

AU - van Erp, T G M

AU - Potkin, S G

AU - Roiz-Santiañez, R

AU - Crespo-Facorro, B

AU - Suarez-Pinilla, P

AU - Van Haren, N E M

AU - de Zwarte, S M C

AU - Kahn, R S

AU - Cahn, W

AU - Doan, N T

AU - Jørgensen, K N

AU - Gurholt, T P

AU - Agartz, I

AU - Andreassen, O A

AU - Westlye, L T

AU - Melle, I

AU - Berg, A O

AU - Mørch-Johnsen, L

AU - Faerden, A

AU - Flyckt, L

AU - Fatouros-Bergman, H

AU - Jönsson, E G

AU - Hashimoto, R

AU - Yamamori, H

AU - Fukunaga, M

AU - Preda, A

AU - De Rossi, P

AU - Piras, F

AU - Banaj, N

AU - Ciullo, V

AU - Spalletta, G

AU - Gur, R E

AU - Gur, R C

AU - Wolf, D H

AU - Satterthwaite, T D

AU - Beard, L M

AU - Sommer, I E

AU - Koops, S

AU - Gruber, O

AU - Richter, A

AU - Krämer, B

AU - Donohoe, G

AU - Cannon, D M

AU - Corvin, A

AU - Di Giorgio, A

AU - Bertolino, A

AU - Lawrie, S

AU - (KaSP), Karolinska Schizophrenia Project Consortium

PY - 2017/5

Y1 - 2017/5

N2 - OBJECTIVE: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.METHOD: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.RESULTS: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = -0.052; P = 0.021; right: βstd = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.CONCLUSION: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

AB - OBJECTIVE: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia.METHOD: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness.RESULTS: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = -0.052; P = 0.021; right: βstd = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness.CONCLUSION: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

KW - Adult

KW - Brain Mapping

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Prospective Studies

KW - Psychiatric Status Rating Scales

KW - Schizophrenia

KW - Schizophrenic Psychology

KW - Temporal Lobe

KW - Journal Article

KW - Meta-Analysis

KW - Multicenter Study

U2 - 10.1111/acps.12718

DO - 10.1111/acps.12718

M3 - Article

SN - 0001-690X

VL - 135

SP - 439

EP - 447

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 5

ER -

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this