Population structure and evolutionary dynamics of pathogenic bacteria

John Maynard Smith, Edward J. Feil, Noel H. Smith

Research output: Contribution to journalReview articlepeer-review

179 Citations (SciVal)

Abstract

Evidence concerning the significance of recombination within natural bacterial populations has historically come from two main sources: Multilocus enzyme electrophoresis (MLEE) and nucleotide sequence data. Here we discuss evidence from a third method, multilocus sequence typing (MLST), which is a development of MLEE based on nucleotide sequencing that combines the advantages of both approaches. MLST has confirmed both the existence of clones and the high rates of recombination for several bacterial pathogens. The data are consistent with 'epidemic' population structures, where clones are superimposed upon a backdrop of frequent recombination, thus, in the short term, resisting the homogenising effect of recombination. The nature of the selective advantage of clones, however, and how this advantage relates to virulence are unclear. The current evidence also has broader implications concerning bacterial species definition, the management of antibiotic-resistant bacteria and the assessment of the dangers of releasing genetically modified organisms into the environment. BioEssays 22:1115-1122, 2000. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish
Pages (from-to)1115-1122
Number of pages8
JournalBioessays
Volume22
Issue number12
DOIs
Publication statusPublished - 10 Nov 2000

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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