Population genetics, taxonomy, phylogeny and evolution of Borrelia burgdorferi sensu lato

Gabriele Margos, Stephanie A Vollmer, Nicholas H Ogden, Durland Fish

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189 Citations (SciVal)
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In order to understand the population structure and dynamics of bacterial microorganisms, typing systems that accurately reflect the phylogenetic and evolutionary relationship of the agents are required. Over the past 15 years multilocus sequence typing schemes have replaced single locus approaches, giving novel insights into phylogenetic and evolutionary relationships of many bacterial species and facilitating taxonomy. Since 2004, several schemes using multiple loci have been developed to better understand the taxonomy, phylogeny and evolution of Lyme borreliosis spirochetes and in this paper we have reviewed and summarized the progress that has been made for this important group of vector-borne zoonotic bacteria.
Original languageEnglish
Pages (from-to)1545-1563
Number of pages19
JournalInfection, Genetics and Evolution
Issue number7
Publication statusPublished - Oct 2011


  • molecular ecology
  • MLST
  • Borrelia burgdorferi
  • ixodes
  • evolution
  • multilocus sequence typing


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