Population genetics on islands connected by an arbitrary network

An analytic approach

George W.A. Constable, Alan J. McKane

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We analyse a model consisting of a population of individuals which is subdivided into a finite set of demes, each of which has a fixed but differing number of individuals. The individuals can reproduce, die and migrate between the demes according to an arbitrary migration network. They are haploid, with two alleles present in the population; frequency-independent selection is also incorporated, where the strength and direction of selection can vary from deme to deme. The system is formulated as an individual-based model and the diffusion approximation systematically applied to express it as a set of nonlinear coupled stochastic differential equations. These can be made amenable to analysis through the elimination of fast-time variables. The resulting reduced model is analysed in a number of situations, including migration-selection balance leading to a polymorphic equilibrium of the two alleles and an illustration of how the subdivision of the population can lead to non-trivial behaviour in the case where the network is a simple hub. The method we develop is systematic, may be applied to any network, and agrees well with the results of simulations in all cases studied and across a wide range of parameter values.

Original languageEnglish
Pages (from-to)149-165
Number of pages17
JournalJournal of Theoretical Biology
Volume358
Early online date1 Jun 2014
DOIs
Publication statusPublished - 7 Oct 2014

Fingerprint

Population Genetics
Islands
population genetics
Migration
Arbitrary
Alleles
Population
alleles
Individual-based Model
Diffusion Approximation
Reduced Model
Haploidy
founder effect
Subdivision
haploidy
Stochastic Equations
Elimination
Finite Set
Differential equations
Express

Keywords

  • Fast-mode reduction
  • Metapopulation
  • Migration
  • Moran model
  • Selection

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Population genetics on islands connected by an arbitrary network : An analytic approach. / Constable, George W.A.; McKane, Alan J.

In: Journal of Theoretical Biology, Vol. 358, 07.10.2014, p. 149-165.

Research output: Contribution to journalArticle

Constable, George W.A. ; McKane, Alan J. / Population genetics on islands connected by an arbitrary network : An analytic approach. In: Journal of Theoretical Biology. 2014 ; Vol. 358. pp. 149-165.
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