Poly(oligo(ethylene glycol) vinyl acetate)s: A Versatile Class of Thermoresponsive and Biocompatible Polymers

Guillaume G. Hedir; Maria C. Arno; Marvin Langlais; Jonathan T. Husband; Rachel K. O'Reilly; Andrew P. Dove

doi:10.1002/anie.201703763

Poly(oligo(ethylene glycol) vinyl acetate)s: A Versatile Class of Thermoresponsive and Biocompatible Polymers

Guillaume G. Hedir
, Maria C. Arno
, Marvin Langlais
, Jonathan T. Husband
, Rachel K. O'Reilly
, Andrew P. Dove

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

57 Citations (SciVal)

Abstract

Abstract:Polymerswithathermallytriggeredphasetransitionareimportantin thedesignof materialsfor biologicalapplications,wheretheirbehaviorcanbe usedto triggerreleaseor (dis)assemblyevents.Despitetheiradvantages,asystemwithtunablethermalresponse,end-groupreactivesites,low toxicity, and controlled main-chain degradability has not been realized, yet this would be a significant advance. The versatile
newpoly(oligo(ethyleneglycol)vinylacetate)s are presented with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Further-more, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end - group, and moreover show that this class of polymers can uniquely be copolymerized with2-methylene-1,3-dioxepane(MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently

Original language	English
Journal	Angewandte Chemie International Edition
DOIs	https://doi.org/10.1002/anie.201703763
Publication status	Published - 2 Jun 2017

Bibliographical note

The University of Warwick and BP as well as the Warwick Institute of Advanced Studyand Materials GRP are thanked for co-funding a scholarship to G.G.H.,and the Royal Society are thanked for the award of an Industry Fellowship to A.P.D. ERC are acknowledged for funding to support R.K.O.(Grant number:615142) and A.P.D.(Grant number: 681559).M.L. thanks ERASMUS for funding an exchange project.

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@article{989363dcb2504af692e0cbe891f84b2f,

title = "Poly(oligo(ethylene glycol) vinyl acetate)s: A Versatile Class of Thermoresponsive and Biocompatible Polymers",

abstract = "Abstract:Polymerswithathermallytriggeredphasetransitionareimportantin thedesignof materialsfor biologicalapplications,wheretheirbehaviorcanbe usedto triggerreleaseor (dis)assemblyevents.Despitetheiradvantages,asystemwithtunablethermalresponse,end-groupreactivesites,low toxicity, and controlled main-chain degradability has not been realized, yet this would be a significant advance. The versatile newpoly(oligo(ethyleneglycol)vinylacetate)s are presented with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Further-more, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end - group, and moreover show that this class of polymers can uniquely be copolymerized with2-methylene-1,3-dioxepane(MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently",

author = "Hedir, \{Guillaume G.\} and Arno, \{Maria C.\} and Marvin Langlais and Husband, \{Jonathan T.\} and O'Reilly, \{Rachel K.\} and Dove, \{Andrew P.\}",

note = "The University of Warwick and BP as well as the Warwick Institute of Advanced Studyand Materials GRP are thanked for co-funding a scholarship to G.G.H.,and the Royal Society are thanked for the award of an Industry Fellowship to A.P.D. ERC are acknowledged for funding to support R.K.O.(Grant number:615142) and A.P.D.(Grant number: 681559).M.L. thanks ERASMUS for funding an exchange project. ",

year = "2017",

month = jun,

day = "2",

doi = "10.1002/anie.201703763",

language = "English",

journal = "Angewandte Chemie International Edition",

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TY - JOUR

T1 - Poly(oligo(ethylene glycol) vinyl acetate)s

T2 - A Versatile Class of Thermoresponsive and Biocompatible Polymers

AU - Hedir, Guillaume G.

AU - Arno, Maria C.

AU - Langlais, Marvin

AU - Husband, Jonathan T.

AU - O'Reilly, Rachel K.

AU - Dove, Andrew P.

N1 - The University of Warwick and BP as well as the Warwick Institute of Advanced Studyand Materials GRP are thanked for co-funding a scholarship to G.G.H.,and the Royal Society are thanked for the award of an Industry Fellowship to A.P.D. ERC are acknowledged for funding to support R.K.O.(Grant number:615142) and A.P.D.(Grant number: 681559).M.L. thanks ERASMUS for funding an exchange project.

PY - 2017/6/2

Y1 - 2017/6/2

N2 - Abstract:Polymerswithathermallytriggeredphasetransitionareimportantin thedesignof materialsfor biologicalapplications,wheretheirbehaviorcanbe usedto triggerreleaseor (dis)assemblyevents.Despitetheiradvantages,asystemwithtunablethermalresponse,end-groupreactivesites,low toxicity, and controlled main-chain degradability has not been realized, yet this would be a significant advance. The versatile newpoly(oligo(ethyleneglycol)vinylacetate)s are presented with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Further-more, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end - group, and moreover show that this class of polymers can uniquely be copolymerized with2-methylene-1,3-dioxepane(MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently

AB - Abstract:Polymerswithathermallytriggeredphasetransitionareimportantin thedesignof materialsfor biologicalapplications,wheretheirbehaviorcanbe usedto triggerreleaseor (dis)assemblyevents.Despitetheiradvantages,asystemwithtunablethermalresponse,end-groupreactivesites,low toxicity, and controlled main-chain degradability has not been realized, yet this would be a significant advance. The versatile newpoly(oligo(ethyleneglycol)vinylacetate)s are presented with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Further-more, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end - group, and moreover show that this class of polymers can uniquely be copolymerized with2-methylene-1,3-dioxepane(MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently

U2 - 10.1002/anie.201703763

DO - 10.1002/anie.201703763

M3 - Article

SN - 1521-3773

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

ER -

Poly(oligo(ethylene glycol) vinyl acetate)s: A Versatile Class of Thermoresponsive and Biocompatible Polymers

Abstract

Bibliographical note

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