Poly(oligo(ethylene glycol) vinyl acetate)s: A Versatile Class of Thermoresponsive and Biocompatible Polymers

Guillaume G. Hedir, Maria C. Arno, Marvin Langlais, Jonathan T. Husband, Rachel K. O'Reilly, Andrew P. Dove

Research output: Contribution to journalArticlepeer-review

51 Citations (SciVal)

Abstract

Abstract:Polymerswithathermallytriggeredphasetransitionareimportantin thedesignof materialsfor biologicalapplications,wheretheirbehaviorcanbe usedto triggerreleaseor (dis)assemblyevents.Despitetheiradvantages,asystemwithtunablethermalresponse,end-groupreactivesites,low toxicity, and controlled main-chain degradability has not been realized, yet this would be a significant advance. The versatile
newpoly(oligo(ethyleneglycol)vinylacetate)s are presented with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Further-more, we demonstrate structure-controlled thermal transitions, conjugation to human lysozyme through the retained end - group, and moreover show that this class of polymers can uniquely be copolymerized with2-methylene-1,3-dioxepane(MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently
Original languageEnglish
JournalAngewandte Chemie International Edition
DOIs
Publication statusPublished - 2 Jun 2017

Bibliographical note

The University of Warwick and BP as well as the Warwick Institute of Advanced Studyand Materials GRP are thanked for co-funding a scholarship to G.G.H.,and the Royal Society are thanked for the award of an Industry Fellowship to A.P.D. ERC are acknowledged for funding to support R.K.O.(Grant number:615142) and A.P.D.(Grant number: 681559).M.L. thanks ERASMUS for funding an exchange project.

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