Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors

Jingjing Gong; Seshasailam Venkateswaran; Michael G. Tanner; James M. Stone; Mark Bradley

doi:10.1021/acscombsci.9b00031

Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors

Jingjing Gong, Seshasailam Venkateswaran, Michael G. Tanner, James M. Stone, Mark Bradley

Department of Physics

Research output: Contribution to journal › Article › peer-review

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Abstract

Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of poly(methyl methacrylate-co-2-(dimethylamino) ethyl acrylate) (PA101), which allowed, via dip coating, the attachment of fluorescent pH sensors onto the tips of optical fibers, resulting in robust, rapid, and reproducible sensing of physiological pHs.

Original language	English
Pages (from-to)	417-424
Number of pages	8
Journal	ACS Combinatorial Science
Volume	21
Issue number	5
Early online date	11 Apr 2019
DOIs	https://doi.org/10.1021/acscombsci.9b00031
Publication status	Published - 13 May 2019

Funding

J.G. acknowledges support from the Chinese Scholarship Council and the Great Britain-China Educational Trust. This work was supported by the European Research Council (Advanced Grant ADREEM ERC-2013-340469). We thank Fuad Mohamad for their help in the pH measurements by the optical-fiber sensor.

Keywords

high-throughput screening
optical fiber
pH sensor
polymer microarray

ASJC Scopus subject areas

General Chemistry

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10.1021/acscombsci.9b00031

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This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Comb. Sci copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acscombsci.9b00031.
Accepted author manuscript, 1.58 MB

Cite this

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abstract = "Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of poly(methyl methacrylate-co-2-(dimethylamino) ethyl acrylate) (PA101), which allowed, via dip coating, the attachment of fluorescent pH sensors onto the tips of optical fibers, resulting in robust, rapid, and reproducible sensing of physiological pHs.",

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Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors

Abstract

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Keywords

ASJC Scopus subject areas

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