Abstract
Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of poly(methyl methacrylate-co-2-(dimethylamino) ethyl acrylate) (PA101), which allowed, via dip coating, the attachment of fluorescent pH sensors onto the tips of optical fibers, resulting in robust, rapid, and reproducible sensing of physiological pHs.
Original language | English |
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Pages (from-to) | 417-424 |
Number of pages | 8 |
Journal | ACS Combinatorial Science |
Volume | 21 |
Issue number | 5 |
Early online date | 11 Apr 2019 |
DOIs | |
Publication status | Published - 13 May 2019 |
Funding
J.G. acknowledges support from the Chinese Scholarship Council and the Great Britain-China Educational Trust. This work was supported by the European Research Council (Advanced Grant ADREEM ERC-2013-340469). We thank Fuad Mohamad for their help in the pH measurements by the optical-fiber sensor.
Keywords
- high-throughput screening
- optical fiber
- pH sensor
- polymer microarray
ASJC Scopus subject areas
- General Chemistry