Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors

Jingjing Gong, Seshasailam Venkateswaran, Michael G. Tanner, James M. Stone, Mark Bradley

Research output: Contribution to journalArticle

3 Downloads (Pure)

Abstract

Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of poly(methyl methacrylate-co-2-(dimethylamino) ethyl acrylate) (PA101), which allowed, via dip coating, the attachment of fluorescent pH sensors onto the tips of optical fibers, resulting in robust, rapid, and reproducible sensing of physiological pHs.

Original languageEnglish
Pages (from-to)417-424
Number of pages8
JournalACS Combinatorial Science
Volume21
Issue number5
Early online date11 Apr 2019
DOIs
Publication statusPublished - 13 May 2019

Keywords

  • high-throughput screening
  • optical fiber
  • pH sensor
  • polymer microarray

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors. / Gong, Jingjing; Venkateswaran, Seshasailam; Tanner, Michael G.; Stone, James M.; Bradley, Mark.

In: ACS Combinatorial Science, Vol. 21, No. 5, 13.05.2019, p. 417-424.

Research output: Contribution to journalArticle

Gong, Jingjing ; Venkateswaran, Seshasailam ; Tanner, Michael G. ; Stone, James M. ; Bradley, Mark. / Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors. In: ACS Combinatorial Science. 2019 ; Vol. 21, No. 5. pp. 417-424.
@article{26b193a2fbe34b35bc7e0a6d7fd6e40e,
title = "Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors",
abstract = "Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of poly(methyl methacrylate-co-2-(dimethylamino) ethyl acrylate) (PA101), which allowed, via dip coating, the attachment of fluorescent pH sensors onto the tips of optical fibers, resulting in robust, rapid, and reproducible sensing of physiological pHs.",
keywords = "high-throughput screening, optical fiber, pH sensor, polymer microarray",
author = "Jingjing Gong and Seshasailam Venkateswaran and Tanner, {Michael G.} and Stone, {James M.} and Mark Bradley",
year = "2019",
month = "5",
day = "13",
doi = "10.1021/acscombsci.9b00031",
language = "English",
volume = "21",
pages = "417--424",
journal = "ACS Combinatorial Science",
issn = "2156-8952",
publisher = "American Chemical Society",
number = "5",

}

TY - JOUR

T1 - Polymer Microarrays for the Discovery and Optimization of Robust Optical-Fiber-Based pH Sensors

AU - Gong, Jingjing

AU - Venkateswaran, Seshasailam

AU - Tanner, Michael G.

AU - Stone, James M.

AU - Bradley, Mark

PY - 2019/5/13

Y1 - 2019/5/13

N2 - Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of poly(methyl methacrylate-co-2-(dimethylamino) ethyl acrylate) (PA101), which allowed, via dip coating, the attachment of fluorescent pH sensors onto the tips of optical fibers, resulting in robust, rapid, and reproducible sensing of physiological pHs.

AB - Polymer microarrays were utilized for the high-throughput screening and discovery of optimal polymeric substrates capable of trapping functional ratiometric fluorescence-based pH sensors. This led to the identification of poly(methyl methacrylate-co-2-(dimethylamino) ethyl acrylate) (PA101), which allowed, via dip coating, the attachment of fluorescent pH sensors onto the tips of optical fibers, resulting in robust, rapid, and reproducible sensing of physiological pHs.

KW - high-throughput screening

KW - optical fiber

KW - pH sensor

KW - polymer microarray

UR - http://www.scopus.com/inward/record.url?scp=85065100181&partnerID=8YFLogxK

U2 - 10.1021/acscombsci.9b00031

DO - 10.1021/acscombsci.9b00031

M3 - Article

VL - 21

SP - 417

EP - 424

JO - ACS Combinatorial Science

JF - ACS Combinatorial Science

SN - 2156-8952

IS - 5

ER -