Polar organometallic strategies for regioselective C-H metallation of N-heterocyclic carbenes

Marina Uzelac, Eva Hevia

Research output: Contribution to journalArticlepeer-review

23 Citations (SciVal)

Abstract

N-Heterocyclic carbenes (NHCs) have become indispensable ligands across a broad swathe of the synthetic and catalytic landscape, not in small part due to their ease of electronic and steric tunability. One of the latest additions to this important family of ligands are anionic NHCs, which have become valuable precursors to access abnormal NHC complexes as well as shown great potential for further NHC functionalisation. Deprotonative metallation has emerged as one of the most versatile methodologies to access anionic NHCs, where judicious choice of reaction conditions and metallating agents can finely tune the regioselectivity of the reaction. This Feature Article focuses on the recent emergence of s-block metal-mediated NHC metallations and the new opportunities this methodology offers.

Original languageEnglish
Pages (from-to)2455-2462
Number of pages8
JournalChemical Communications
Volume54
Issue number20
DOIs
Publication statusPublished - 23 Jan 2018

Bibliographical note

Funding Information:
We are grateful to all the colleagues whose names appear in the cited publications for their contribution to the development of the presented work. We are especially appreciative of Professor Robert E. Mulvey for his insightful comments and discussion. Funding is acknowledged from the European Research Council (ERC) MIXMETAPPS-279590 FP7 project and the EPSRC project ‘‘Towards a Paradigm Shift in the Principles and Practice of Polar Organometallic Chemistry’’, grant number EP/N011384/1.

Publisher Copyright:
© 2018 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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