Point-of-Care Diagnostics in Low Resource Settings: Present Status and Future Role of Microfluidics

Shikha Sharma, Julia Zapatero-Rodriguez, Pedro Estrela, Richard O'Kennedy

Research output: Contribution to journalReview article

107 Citations (Scopus)
52 Downloads (Pure)

Abstract

The inability to diagnose numerous diseases rapidly is a significant cause of the disparity of deaths resulting from both communicable and non-communicable diseases in the developing world in comparison to the developed world. Existing diagnostic instrumentation usually requires sophisticated infrastructure, stable electrical power, expensive reagents, long assay times, and highly trained personnel which is not often available in limited resource settings. This review will critically survey and analyse the current lateral flow-based point-of-care (POC) technologies, which have made a major impact on diagnostic testing in developing countries over the last 50 years. The future of POC technologies including the applications of microfluidics, which allows miniaturisation and integration of complex functions that facilitate their usage in limited resource settings, is discussed The advantages offered by such systems, including low cost, ruggedness and the capacity to generate accurate and reliable results rapidly, are well suited to the clinical and social settings of the developing world.
Original languageEnglish
Pages (from-to)577-601
Number of pages25
JournalBiosensors
Volume5
Issue number3
DOIs
Publication statusPublished - 13 Aug 2015

Fingerprint

Point-of-Care Systems
Microfluidics
Miniaturization
Developing countries
Developing Countries
Cause of Death
Assays
Personnel
Costs and Cost Analysis
Testing
Costs

Keywords

  • low-cost biosensors
  • point-of-care diagnostics
  • lateral flow immunoassay
  • microfluidics
  • global health

Cite this

Point-of-Care Diagnostics in Low Resource Settings: Present Status and Future Role of Microfluidics. / Sharma, Shikha; Zapatero-Rodriguez, Julia; Estrela, Pedro; O'Kennedy, Richard.

In: Biosensors, Vol. 5, No. 3, 13.08.2015, p. 577-601.

Research output: Contribution to journalReview article

Sharma, Shikha ; Zapatero-Rodriguez, Julia ; Estrela, Pedro ; O'Kennedy, Richard. / Point-of-Care Diagnostics in Low Resource Settings: Present Status and Future Role of Microfluidics. In: Biosensors. 2015 ; Vol. 5, No. 3. pp. 577-601.
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