Pleiotropic constraints promote the evolution of cooperation in cellular groups

Michael A. Bentley, Christian A. Yates, Jotun Hein, Gail M. Preston, Kevin R. Foster

Research output: Contribution to journalArticlepeer-review

3 Citations (SciVal)

Abstract

AU The:evolution Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly of cooperation in cellular groups is threatened: by lineages of cheaters that proliferate at the expense of the group. These cell lineages occur within microbial communities, and multicellular organisms in the form of tumours and cancer. In contrast to an earlier study, here we show how the evolution of pleiotropic genetic architectures—which link the expression of cooperative and private traits—can protect against cheater lineages and allow cooperation to evolve. We develop an age-structured model of cellular groups and show that cooperation breaks down more slowly within groups that tie expression to a private trait than in groups that do not. We then show that this results in group selection for pleiotropy, which strongly promotes cooperation by limiting the emergence of cheater lineages. These results predict that pleiotropy will rapidly evolve, so long as groups persist long enough for cheater lineages to threaten cooperation. Our results hold when pleiotropic links can be undermined by mutations, when pleiotropy is itself costly, and in mixed-genotype groups such as those that occur in microbes. Finally, we consider features of multicellular organisms—a germ line and delayed reproductive maturity—and show that pleiotropy is again predicted to be important for maintaining cooperation. The study of cancer in multicellular organisms provides the best evidence for pleiotropic constraints, where abberant cell proliferation is linked to apoptosis, senescence, and terminal differentiation. Alongside development from a single cell, we propose that the evolution of pleiotropic constraints has been critical for cooperation in many cellular groups.

Original languageEnglish
Article numbere3001626
JournalPLoS Biology
Volume20
Issue number6
DOIs
Publication statusPublished - 3 Jun 2022

Bibliographical note

KRF received a European Research Council Grant 787932 for this research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Fingerprint

Dive into the research topics of 'Pleiotropic constraints promote the evolution of cooperation in cellular groups'. Together they form a unique fingerprint.

Cite this