Claisen–Schmidt condensations, yielding only water as a by-product, performed on building blocks serving as shape-selective male or female terminals and unions, enable the preparation of diverse molecular structures including novel linear rods and semi-elliptical, rectangular or trapezoidal macrocycles. Isoaromatization affords a corresponding range of phenol-formaldehyde derivatives, in atom economical reactions.
Giarrusso, M. A., Higham, L. T., Kreher, U. P., Mohan, R. S., Rosamilia, A. E., Scott, J. L., & Strauss, C. R. (2008). Platform technology for dienone and phenol–formaldehyde architectures. Green Chemistry, 10(8), 842-852. https://doi.org/10.1039/B802755B