Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen-Bonding Catalysis through Positive Cooperativity

Christopher R. Jones; G. Dan Pantos; Angus J. Morrison; Martin D. Smith

doi:10.1002/anie.200903063

Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen-Bonding Catalysis through Positive Cooperativity

Christopher R. Jones, G. Dan Pantos, Angus J. Morrison, Martin D. Smith

Research output: Contribution to journal › Article › peer-review

77 Citations (SciVal)

Abstract

A new twist for a fold: Conformationally well‐defined thiourea catalysts, like that shown, stabilized by intramolecular hydrogen bonds demonstrate cooperative ligand–receptor binding. This conformation leads to significantly enhanced catalytic efficiency, resulting in higher turnover rates and lower catalyst loading whilst maintaining high enantioselectivity in a model reaction.

Original language	English
Pages (from-to)	7391-7394
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	48
Issue number	40
DOIs	https://doi.org/10.1002/anie.200903063
Publication status	Published - 2 Sept 2009

Keywords

asymmetric catalysis
cooperativity
hydrogen bonds
thioureas

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10.1002/anie.200903063

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abstract = "A new twist for a fold: Conformationally well‐defined thiourea catalysts, like that shown, stabilized by intramolecular hydrogen bonds demonstrate cooperative ligand–receptor binding. This conformation leads to significantly enhanced catalytic efficiency, resulting in higher turnover rates and lower catalyst loading whilst maintaining high enantioselectivity in a model reaction. ",

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AU - Smith, Martin D.

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KW - asymmetric catalysis

KW - cooperativity

KW - hydrogen bonds

KW - thioureas

U2 - 10.1002/anie.200903063

DO - 10.1002/anie.200903063

M3 - Article

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JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 40

ER -

Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen-Bonding Catalysis through Positive Cooperativity

Abstract

Keywords

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