Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen-Bonding Catalysis through Positive Cooperativity

Christopher R. Jones, G. Dan Pantos, Angus J. Morrison, Martin D. Smith

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A new twist for a fold: Conformationally well‐defined thiourea catalysts, like that shown, stabilized by intramolecular hydrogen bonds demonstrate cooperative ligand–receptor binding. This conformation leads to significantly enhanced catalytic efficiency, resulting in higher turnover rates and lower catalyst loading whilst maintaining high enantioselectivity in a model reaction.
Original languageEnglish
Pages (from-to)7391-7394
Number of pages4
JournalAngewandte Chemie-International Edition
Volume48
Issue number40
DOIs
Publication statusPublished - 2 Sep 2009

Keywords

  • asymmetric catalysis
  • cooperativity
  • hydrogen bonds
  • thioureas

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