A new twist for a fold: Conformationally well‐defined thiourea catalysts, like that shown, stabilized by intramolecular hydrogen bonds demonstrate cooperative ligand–receptor binding. This conformation leads to significantly enhanced catalytic efficiency, resulting in higher turnover rates and lower catalyst loading whilst maintaining high enantioselectivity in a model reaction.
- asymmetric catalysis
- hydrogen bonds
Jones, C. R., Pantos, G. D., Morrison, A. J., & Smith, M. D. (2009). Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen-Bonding Catalysis through Positive Cooperativity. Angewandte Chemie-International Edition, 48(40), 7391-7394. https://doi.org/10.1002/anie.200903063