PKC-interacting proteins: from function to pharmacology

Alastair W Poole, Giordano Pula, Ingeborg Hers, David Crosby, Matthew L Jones

Research output: Contribution to journalArticle

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Abstract

Protein kinase C (PKC) is a ubiquitously expressed family of kinases that have key roles in regulating multiple cellular activities. The activity of this family is controlled tightly by several molecular mechanisms, including interaction with binding-partner proteins. These PKC-interacting proteins (C-KIPs) confer specificity for individual PKC isoforms by regulating the activity and cellular localization of PKC isoforms and, subsequently, the ability of these isoforms to specifically regulate cellular functional events. Although many C-KIPs have been identified by genome and proteome-mining approaches, it is important to address the specificity and function of the interactions in greater detail because they might form novel drug targets. In this article, we review recent work on C-KIPs and the implications for pharmacological and therapeutic development.
Original languageEnglish
Pages (from-to)528-535
Number of pages8
JournalTrends in Pharmacological Sciences
Volume25
Issue number10
DOIs
Publication statusPublished - Oct 2004

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Protein Kinase C
Pharmacology
Protein Isoforms
Proteins
Proteome
Protein C
Carrier Proteins
Phosphotransferases
Genes
Genome
Pharmaceutical Preparations
Therapeutics

Cite this

Poole, A. W., Pula, G., Hers, I., Crosby, D., & Jones, M. L. (2004). PKC-interacting proteins: from function to pharmacology. Trends in Pharmacological Sciences, 25(10), 528-535. https://doi.org/10.1016/j.tips.2004.08.006

PKC-interacting proteins: from function to pharmacology. / Poole, Alastair W; Pula, Giordano; Hers, Ingeborg; Crosby, David; Jones, Matthew L.

In: Trends in Pharmacological Sciences, Vol. 25, No. 10, 10.2004, p. 528-535.

Research output: Contribution to journalArticle

Poole, AW, Pula, G, Hers, I, Crosby, D & Jones, ML 2004, 'PKC-interacting proteins: from function to pharmacology', Trends in Pharmacological Sciences, vol. 25, no. 10, pp. 528-535. https://doi.org/10.1016/j.tips.2004.08.006
Poole, Alastair W ; Pula, Giordano ; Hers, Ingeborg ; Crosby, David ; Jones, Matthew L. / PKC-interacting proteins: from function to pharmacology. In: Trends in Pharmacological Sciences. 2004 ; Vol. 25, No. 10. pp. 528-535.
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