PKC-interacting proteins: from function to pharmacology

Alastair W Poole, Giordano Pula, Ingeborg Hers, David Crosby, Matthew L Jones

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106 Citations (Scopus)

Abstract

Protein kinase C (PKC) is a ubiquitously expressed family of kinases that have key roles in regulating multiple cellular activities. The activity of this family is controlled tightly by several molecular mechanisms, including interaction with binding-partner proteins. These PKC-interacting proteins (C-KIPs) confer specificity for individual PKC isoforms by regulating the activity and cellular localization of PKC isoforms and, subsequently, the ability of these isoforms to specifically regulate cellular functional events. Although many C-KIPs have been identified by genome and proteome-mining approaches, it is important to address the specificity and function of the interactions in greater detail because they might form novel drug targets. In this article, we review recent work on C-KIPs and the implications for pharmacological and therapeutic development.
Original languageEnglish
Pages (from-to)528-535
Number of pages8
JournalTrends in Pharmacological Sciences
Volume25
Issue number10
DOIs
Publication statusPublished - Oct 2004

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    Poole, A. W., Pula, G., Hers, I., Crosby, D., & Jones, M. L. (2004). PKC-interacting proteins: from function to pharmacology. Trends in Pharmacological Sciences, 25(10), 528-535. https://doi.org/10.1016/j.tips.2004.08.006