Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms

Rosa M. Ceinos, Raul Guillot, Robert N. Kelsh, Jose M. Cerda-Reverter, Josep Rotllant

Research output: Contribution to journalArticle

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Abstract

Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, agouti-signalling peptide (ASIP). In fish, studies of pigment patterning have focused on stripe formation, identifying a core striping mechanism dependent upon interactions between different pigment cell types. In contrast, mechanisms driving the dorso-ventral countershading pattern have been overlooked. Here, we demonstrate that, in fact, zebrafish utilize two distinct adult pigment patterning mechanisms – an ancient dorso-ventral patterning mechanism, and a more recent striping mechanism based on cell–cell interactions; remarkably, the dorso-ventral patterning mechanism also utilizes ASIP. These two mechanisms function largely independently, with resultant patterns superimposed to give the full pattern.
Original languageEnglish
Pages (from-to)196-209
Number of pages14
JournalPigment Cell & Melanoma Research
Volume28
Issue number2
Early online date2 Dec 2014
DOIs
Publication statusPublished - Mar 2015

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Pigmentation
Pigments
Fish
Agouti Signaling Protein
Fishes
Peptides
Melanocytes
Melanins
Zebrafish
Cell Communication
Vertebrates
Mammals
Dasyproctidae

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Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms. / Ceinos, Rosa M.; Guillot, Raul; Kelsh, Robert N.; Cerda-Reverter, Jose M.; Rotllant, Josep.

In: Pigment Cell & Melanoma Research, Vol. 28, No. 2, 03.2015, p. 196-209.

Research output: Contribution to journalArticle

Ceinos, Rosa M. ; Guillot, Raul ; Kelsh, Robert N. ; Cerda-Reverter, Jose M. ; Rotllant, Josep. / Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms. In: Pigment Cell & Melanoma Research. 2015 ; Vol. 28, No. 2. pp. 196-209.
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