Abstract
Aberrant overactivation of the immune system can give rise to chronic and persistent self-attack, culminating in autoimmune disease. This is currently managed therapeutically using potent immunosuppressive and anti-inflammatory drugs. Class I phosphoinositide 3-kinases (PI3Ks) have been identified as ideal therapeutic targets for autoimmune diseases given their wide-ranging roles in immunological processes. Recent studies into the function of selective PI3K inhibitors in vitro and in vivo have yielded encouraging results, allowing progression into the clinic. Here, we review their recent progress across a range of autoimmune diseases.
Original language | English |
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Pages (from-to) | 1195-1199 |
Number of pages | 5 |
Journal | Drug Discovery Today |
Volume | 19 |
Issue number | 8 |
Early online date | 13 Apr 2014 |
DOIs | |
Publication status | Published - Aug 2014 |
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Stephen Ward
- Department of Life Sciences - Professor
- Centre for Therapeutic Innovation
- Centre for Bioengineering & Biomedical Technologies (CBio)
Person: Research & Teaching, Affiliate staff