Phosphatidylinositol metabolism and membrane fusion

Dominic Poccia, Banafshé Larijani

Research output: Contribution to journalReview articlepeer-review

Abstract

Membrane fusion underliesmany cellular events, including secretion, exocytosis, endocytosis, organelle reconstitution, transport from endoplasmic reticulum to Golgi and nuclear envelope formation. A large number of investigations into membrane fusion indicate various roles for individual members of the phosphoinositide class of membrane lipids. We first review the phosphoinositides as membrane recognition sites and their regulatory functions in membrane fusion. We then consider how modulation of phosphoinositides and their products may affect the structure and dynamics of natural membranes facilitating fusion. These diverse roles underscore the importance of these phospholipids in the fusion of biological membranes.

Original languageEnglish
Pages (from-to)233-246
Number of pages14
JournalBiochemical Journal
Volume418
Issue number2
DOIs
Publication statusPublished - 11 Feb 2009

Keywords

  • Diacylglycerol
  • Membrane curvature
  • Membrane fusion
  • Nuclear envelope
  • Phosphoinositide-specific phospholipase C (PI-PLC)
  • Soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor (SNARE)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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