Phenol-soluble modulins are secreted peptides with multiple functions in Staphylococcus aureus pathogenesis and spreading. Recent studies by Otto and coworkers show that these hellhounds of the staphylococcal virulence-factor pandemonium are unleashed through an essential ABC transporter, which represents an exciting new target for stopping the spread of this important pathogen.
- ATP-Binding Cassette Transporters/metabolism
- Bacterial Toxins/metabolism
- Staphylococcal Skin Infections/microbiology
- Staphylococcus aureus/pathogenicity