Pharmacokinetics of percutaneous absorption with concurrent metabolism

Richard H. Guy; Jonathan Hadgraft

doi:10.1016/0378-5173(84)90216-3

Pharmacokinetics of percutaneous absorption with concurrent metabolism

Research output: Contribution to journal › Article › peer-review

Abstract

A pharmacokinetic model for percutaneous absorption has been formulated which allows calculation of the drug disposition in the skin, plasma and urine. Allowance is also made for metabolic processes within the skin. The influence of metabolism on the concentrations of the parent molecule and the metabolite in the plasma is discussed.

Original language	English
Pages (from-to)	43-51
Number of pages	9
Journal	International Journal of Pharmaceutics
Volume	20
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-5173(84)90216-3
Publication status	Published - 1984

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/0378-5173(84)90216-3

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title = "Pharmacokinetics of percutaneous absorption with concurrent metabolism",

abstract = "A pharmacokinetic model for percutaneous absorption has been formulated which allows calculation of the drug disposition in the skin, plasma and urine. Allowance is also made for metabolic processes within the skin. The influence of metabolism on the concentrations of the parent molecule and the metabolite in the plasma is discussed.",

author = "Guy, {Richard H.} and Jonathan Hadgraft",

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T1 - Pharmacokinetics of percutaneous absorption with concurrent metabolism

AU - Guy, Richard H.

AU - Hadgraft, Jonathan

PY - 1984

Y1 - 1984

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AB - A pharmacokinetic model for percutaneous absorption has been formulated which allows calculation of the drug disposition in the skin, plasma and urine. Allowance is also made for metabolic processes within the skin. The influence of metabolism on the concentrations of the parent molecule and the metabolite in the plasma is discussed.

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DO - 10.1016/0378-5173(84)90216-3

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AN - SCOPUS:0021256155

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VL - 20

SP - 43

EP - 51

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Pharmacokinetics of percutaneous absorption with concurrent metabolism

Abstract

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