Percutaneous metabolism with saturable enzyme kinetics

Richard H. Guy; Jonathan Hadgraft

doi:10.1016/0378-5173(82)90037-0

Percutaneous metabolism with saturable enzyme kinetics

Richard H. Guy
, Jonathan Hadgraft

School of Pharmacy
University of California San Francisco
University of Nottingham

Research output: Contribution to journal › Article › peer-review

Abstract

Theoretical equations have been formulated to describe the effect of epidermal metabolic processes on the transport of drugs penetrating the skin. Michaelis-Menten kinetics have been assumed and the relative contributions from the kinetic parameters discussed.

Original language	English
Pages (from-to)	187-197
Number of pages	11
Journal	International Journal of Pharmaceutics
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0378-5173(82)90037-0
Publication status	Published - Jul 1982

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/0378-5173(82)90037-0

Cite this

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title = "Percutaneous metabolism with saturable enzyme kinetics",

abstract = "Theoretical equations have been formulated to describe the effect of epidermal metabolic processes on the transport of drugs penetrating the skin. Michaelis-Menten kinetics have been assumed and the relative contributions from the kinetic parameters discussed.",

author = "Guy, \{Richard H.\} and Jonathan Hadgraft",

year = "1982",

month = jul,

doi = "10.1016/0378-5173(82)90037-0",

language = "English",

volume = "11",

pages = "187--197",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier B.V.",

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T1 - Percutaneous metabolism with saturable enzyme kinetics

AU - Guy, Richard H.

AU - Hadgraft, Jonathan

PY - 1982/7

Y1 - 1982/7

N2 - Theoretical equations have been formulated to describe the effect of epidermal metabolic processes on the transport of drugs penetrating the skin. Michaelis-Menten kinetics have been assumed and the relative contributions from the kinetic parameters discussed.

AB - Theoretical equations have been formulated to describe the effect of epidermal metabolic processes on the transport of drugs penetrating the skin. Michaelis-Menten kinetics have been assumed and the relative contributions from the kinetic parameters discussed.

UR - https://www.scopus.com/pages/publications/0001329919

U2 - 10.1016/0378-5173(82)90037-0

DO - 10.1016/0378-5173(82)90037-0

M3 - Article

AN - SCOPUS:0001329919

SN - 0378-5173

VL - 11

SP - 187

EP - 197

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 3

ER -

Percutaneous metabolism with saturable enzyme kinetics

Abstract

ASJC Scopus subject areas

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