Percutaneous absorption of hydroquinone in humans: Effect of 1-dodecylazacycloheptan-2-one (azone) and the 2-ethylhexyl ester of 4-(dimethylamino)benzoic acid (escalol 507)

Daniel A.W. Bucks, James R. McMaster, Richard H. Guy, Howard I. Maibach

Research output: Contribution to journalArticlepeer-review

Abstract

Hydroquinone was found to penetrate readily human forehead skin in vivo following a single topical exposure, in an alcoholic vehicle, of 24 h duration. Percutaneous absorption was estimated using radiotracer methodology and14C-labeled hydroquinone. The effects of a penetration enhancer, 1-dodecylazacycloheptan-2-one, and a sunscreen, the 2-ethylhexyl ester of 4-(dimethylamino)benzoic acid, on the percutaneous absorption of hydroquinone were investigated. In vivo penetration of hydroquinone was significantly decreased (a < 0.05) by the addition of the 2-ethylhexyl ester of 4-(dimethylamino)benzoic acid (3% w/w) to the vehicle. The penetration enhancer, 1-dodecylazacycloheptan-2-one (0.5% w/w), did not significantly increase (a > 0.05) the absorption of hydroquinone. From all hydroquinone preparations, percutaneous absorption was rapid and peak elimination occurred within the first 12 h following application. Elimination was complete within 5 d.

Original languageEnglish
Pages (from-to)279-289
Number of pages11
JournalJournal of Toxicology and Environmental Health
Volume24
Issue number3
DOIs
Publication statusPublished - 31 Jul 1988

Bibliographical note

Funding Information:
Funding for this research was provided by Nicholas Kiwi Central Laboratories, Boronia, Australia. R. H. Guy is the recipient of a special emphasis research career award (OH-00017) from NIOSH-CDC.

ASJC Scopus subject areas

  • Toxicology
  • Pollution

Fingerprint

Dive into the research topics of 'Percutaneous absorption of hydroquinone in humans: Effect of 1-dodecylazacycloheptan-2-one (azone) and the 2-ethylhexyl ester of 4-(dimethylamino)benzoic acid (escalol 507)'. Together they form a unique fingerprint.

Cite this