Peptidantibiotika — Frühwarnsysteme und Katastrophenschutz bei Bakterien

Susanne Gebhard; Sebastian Dintner

doi:10.1007/s12268-014-0437-y

Peptidantibiotika — Frühwarnsysteme und Katastrophenschutz bei Bakterien

Translated title of the contribution: Peptide antibiotics - early warning systems and disaster management in bacteria

Susanne Gebhard, Sebastian Dintner

Ludwig Maximilian University of Munich

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Abstract

In their habitats, microorganisms are often in competition for limited nutrients, and many Gram-positive bacteria resort to production of peptide antibiotics to succeed. Consequently, resistance against these compounds is essential. The first step in ensuring survival is the detection of the toxic peptides. Interestingly, many of the sensory proteins lack obvious binding domains. We investigate how such proteins are able to detect their substrates and regulate resistance.

Translated title of the contribution	Peptide antibiotics - early warning systems and disaster management in bacteria
Original language	German
Pages (from-to)	263-266
Number of pages	4
Journal	BIOspektrum
Volume	20
Issue number	3
Early online date	14 May 2014
DOIs	https://doi.org/10.1007/s12268-014-0437-y
Publication status	Published - 14 May 2014

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10.1007/s12268-014-0437-y

Final version_Biospektrum_Gebhard
The final publication is available at Springer via http://dx.doi.org/10.1007/s12268-014-0437-y
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title = "Peptidantibiotika — Fr{\"u}hwarnsysteme und Katastrophenschutz bei Bakterien",

abstract = "In their habitats, microorganisms are often in competition for limited nutrients, and many Gram-positive bacteria resort to production of peptide antibiotics to succeed. Consequently, resistance against these compounds is essential. The first step in ensuring survival is the detection of the toxic peptides. Interestingly, many of the sensory proteins lack obvious binding domains. We investigate how such proteins are able to detect their substrates and regulate resistance.",

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AU - Dintner, Sebastian

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N2 - In their habitats, microorganisms are often in competition for limited nutrients, and many Gram-positive bacteria resort to production of peptide antibiotics to succeed. Consequently, resistance against these compounds is essential. The first step in ensuring survival is the detection of the toxic peptides. Interestingly, many of the sensory proteins lack obvious binding domains. We investigate how such proteins are able to detect their substrates and regulate resistance.

AB - In their habitats, microorganisms are often in competition for limited nutrients, and many Gram-positive bacteria resort to production of peptide antibiotics to succeed. Consequently, resistance against these compounds is essential. The first step in ensuring survival is the detection of the toxic peptides. Interestingly, many of the sensory proteins lack obvious binding domains. We investigate how such proteins are able to detect their substrates and regulate resistance.

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DO - 10.1007/s12268-014-0437-y

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ER -

Peptidantibiotika — Frühwarnsysteme und Katastrophenschutz bei Bakterien

Abstract

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